目的 探討紫杉醇涂層球囊對老年冠心病患者治療效果，及對靶血管直徑、心血管不良事件（MACE）的影響。方法 選擇2020年6月—2022年6月南京醫(yī)科大學附屬無錫人民醫(yī)院收治的老年冠心病患者82例，隨機分為觀察組41例、對照組41例。對照組采用藥物洗脫支架治療，觀察組采用紫杉醇藥物涂層球囊（DCB）治療。比較兩組總有效率、心功能指標、靶病變管腔直徑及狹窄率、MACE發(fā)生率。結(jié)果 術(shù)后，觀察組總有效率（97.56%）較對照組（82.93%）顯著升高（P＜0.05）；觀察組左室射血分數(shù)（LVEF）、每搏輸出量（SV）較本組治療前顯著上升（P＜0.05），且顯著高于對照組（P＜0.05）；觀察組靶病變管腔狹窄率較本組治療前顯著降低（P＜0.05），且顯著低于對照組（P＜0.05），管腔直徑較本組治療前顯著增加（P＜0.05），且顯著大于對照組（P＜0.05）；觀察組MACE發(fā)生率顯著低于對照組（P＜0.05）。結(jié)論 對老年冠心病患者采用紫杉醇涂層球囊治療，可有效緩解患者臨床癥狀，改善心功能，減少MACE發(fā)生率，在臨床上值得推廣。

Objective: To investigate the therapeutic effect of paclitaxel coated balloon on elderly patients with coronary heart disease, and its impact on target vessel diameter and cardiovascular adverse events (MACE). Method A total of 82 elderly patients with coronary heart disease admitted to Wuxi People's Hospital Affiliated to Nanjing Medical University from June 2020 to June 2022 were randomly divided into an observation group of 41 cases and a control group of 41 cases. The control group was treated with drug-eluting stents, while the observation group was treated with paclitaxel coated balloon (DCB). Compare the total effective rate, cardiac function indicators, target lesion lumen diameter and stenosis rate, and MACE incidence between two groups. Results After surgery, the total effective rate of the observation group (97.56%) was significantly higher than that of the control group (82.93%) (P < 0.05). The left ventricular ejection fraction (LVEF) and stroke volume (SV) in the observation group were significantly increased compared to before treatment（P < 0.05）, and were significantly higher than those in the control group（P < 0.05）. The stenosis rate of the target lesion lumen in the observation group was significantly decreased compared to before treatment（P < 0.05）, and significantly lower than that in the control group (P < 0.05). The lumen diameter was significantly increased compared to before treatment（P < 0.05）, and significantly larger than that in the control group (P < 0.05). The incidence of MACE in the observation group was significantly lower than that in the control group (P < 0.05). Conclusion The use of paclitaxel coated balloon therapy for elderly patients with coronary heart disease can effectively alleviate clinical symptoms, improve heart function, and reduce the incidence of MACE. It is worth promoting in clinical practice.

R972