目的 評估和分析1984年—2023年關(guān)于氫嗎啡酮研究的論文數(shù)量和研究現(xiàn)狀、研究熱點(diǎn)以及相關(guān)基因及疾病研究趨勢。方法 采用文獻(xiàn)計(jì)量學(xué)的方法檢索1984年—2023年Web of Science核心數(shù)據(jù)庫（WoS）和中國學(xué)術(shù)期刊全文數(shù)據(jù)庫（CNKI）有關(guān)氫嗎啡酮的文獻(xiàn)，利用多種文獻(xiàn)計(jì)量學(xué)軟件和公共數(shù)據(jù)庫平臺對國家、機(jī)構(gòu)、作者、期刊、共被引文獻(xiàn)、關(guān)鍵詞，基因及疾病進(jìn)行可視化分析。結(jié)果 近40年，有關(guān)氫嗎啡酮的研究發(fā)展迅速，國內(nèi)外數(shù)據(jù)庫中氫嗎啡酮相關(guān)研究均逐年增加，近10年增長更快。中英文關(guān)鍵詞聚類分析顯示，目前對氫嗎啡酮的研究以慢性疼痛、術(shù)后鎮(zhèn)痛、疼痛管理、麻醉為主；氫嗎啡酮研究相關(guān)基因進(jìn)行聚類分析發(fā)現(xiàn)，黏液型阿片樣受體（OPRM1）、腎素結(jié)合蛋白（RENBP）、白細(xì)胞介素6 （IL-6）和CYP450 2D6酶（CYP2D6）熱度較高。白蛋白（ALB）、人胰島素（INS）、PPIG、細(xì)胞色素P450 3A4酶（CYP3A4）、IL-6、腫瘤壞死因子（TNF）、前列腺素內(nèi)過氧化物合酶 2（PTGS2）、阿黑皮素原（POMC）、OPRM1、細(xì)胞色素P450 1A2酶（CYP1A2），這些蛋白可能為與氫嗎啡酮研究密切相關(guān)的核心蛋白。結(jié)論 氫嗎啡酮相關(guān)研究的數(shù)量及質(zhì)量均快速增長，研究熱點(diǎn)集中于癌性疼痛、急慢性疼痛管理、不良反應(yīng)等。這些分析對深入理解氫嗎啡酮的藥效學(xué)和藥動學(xué)及確定未來研究方向提供一定的借鑒。

Objective To evaluate and analyze the number of research papers on hydromorphone from 1984 to 2023, the research status, research hotspots, and research trends of related genes and diseases. Methods The literature related to hydromorphone studies from 1984 to 2023 in the Web of Science Core database (WoS) and China National Knowledge Infrastructure (CNKI) was retrieved by bibliometrics method. A variety of bibliometrics software and public database platform were used to visually analyze countries, institutions, authors, journals, co-cited literatures, keywords, genes and diseases. Results Over the past 40 years, the research on hydromorphone has developed rapidly. And the research on hydromorphone in domestic and foreign databases has increased year by year, and the growth has been faster in the past decade. The current research on hydromorphone mainly focuses on chronic pain, postoperative analgesia, pain management, and anesthesia. Cluster analysis of genes related to hydromorphone study showed that OPRM1, RENBP, IL-6 and CYP2D6 were highly popular. ALB, INS, PPIG, CYP3A4, IL-6, TNF, PTGS2, POMC, OPRM1, CYP1A2 may be the core proteins closely related to hydromorphone research. Conclusion The quantity and quality of hydromorphone related research are increasing rapidly. Research hotspot focused on cancerous pain, acute or chronic pain management, adverse reactions, etc. These analyses provide some reference for further understanding of the pharmacodynamics and pharmacokinetics of hydromorphone and for determining the future research direction.

R982

武漢市科技局2022年度知識創(chuàng)新專項(xiàng)基礎(chǔ)研究項(xiàng)目（2022020801010535）；吳階平醫(yī)學(xué)基金會臨床科研專項(xiàng)資助基金項(xiàng)目（320.6750.2024-11-01）