抑郁癥作為一種常見的心理疾病，給患者的身心健康帶來了巨大的負擔，為社會衛(wèi)生服務體系帶來巨大挑戰(zhàn)。臨床上常用的抗抑郁化學藥物主要是5-羥色胺再攝取抑制劑，療效確切，但存在靶點單一、不良反應大、服藥周期長、患者依從性差等缺點。中醫(yī)藥具有多靶點、多層次、多途徑等特點，且不良反應小，在改善抑郁癥患者癥狀、降低復發(fā)率等方面具有獨到的優(yōu)勢。作為一種藥用歷史悠久的中藥材，丹參在心腦血管疾病的防治中應用廣泛，其針對抑郁癥狀的治療近年來也被頻繁使用，在抗抑郁領(lǐng)域展現(xiàn)出潛在治療效果。對丹參有效成分水溶性成分（丹酚酸B、迷迭香酸、咖啡酸、丹參素鈉）、脂溶性成分（丹參酮、丹參酮Ⅱ_A、隱丹參酮）及丹參類制劑（注射用丹參多酚酸、復方丹參滴丸等）在抗抑郁藥理作用及機制的研究進展進行系統(tǒng)總結(jié)，旨在為丹參進一步開發(fā)和臨床應用提供科學依據(jù)，為抑郁癥治療提供新思路。

As a common mental illness, depression has brought a huge burden to the physical and mental health of patients and brought great challenges to the social health service system. The commonly used antidepressant chemical drugs in clinical practice are serotonin reuptake inhibitors, which have definite therapeutic effects. However, they have disadvantages such as single target, large adverse reactions, long medication cycles, and poor patient compliance. Traditional Chinese medicine has the characteristics of multi-target, multi-level, and multi pathway, and has minimal adverse reactions. It has unique advantages in improving symptoms of depression patients and reducing recurrence rates. As a traditional Chinese medicine with a long history, Salviae Miltiorrhizae Radixet Rhizomais widely used in the prevention and treatment of cardiovascular and cerebrovascular diseases. Its treatment for depressive symptoms has also been frequently used in recent years, showing potential therapeutic effects in the field of antidepressants. In this paper, the research progress of water-soluble components (salvianolic acid B, rosmarinic acid, caffeic acid, sodium danshensu), fat-soluble components (tanshinone, tanshinone II_A, cryptotanshinone) and salvia preparations (Salvianolic Acids for Injection, Compound Danshen Dropping Pills, etc.) in antidepressant pharmacological effects were systematically summarized, aiming to provide scientific basis for the further development and clinical application of Salviae Miltiorrhizae Radix et Rhizoma, and provide new ideas for the treatment of depression.

R285.5

天津市制造業(yè)高質(zhì)量發(fā)展專項資金—天津天士力之驕藥業(yè)有限公司技術(shù)中心創(chuàng)新能力建設(shè)（ZZY20232088）