骨質(zhì)疏松癥（OP）是一種常見的全身性代謝性骨病。依據(jù)病因，OP可分為原發(fā)性O(shè)P和繼發(fā)性O(shè)P。OP主要表現(xiàn)為骨密度（BMD）降低和骨質(zhì)破壞，容易導(dǎo)致骨折和功能障礙。臨床上主要采用抑制骨吸收藥物降鈣素以及促進(jìn)骨形成藥物甲狀旁腺激素等化學(xué)藥物治療OP，常用的抗OP中藥有黃芪以及紅芪-淫羊藿復(fù)方等。紅芪為補益類中藥，具有抗炎、免疫調(diào)節(jié)、抗氧化、防治糖尿病并發(fā)癥等廣泛的藥理作用，歷代本草中多將紅芪列入黃芪項下，作為黃芪使用，紅芪在增強免疫力、清除自由基活性、抗肝纖維化方面要優(yōu)于黃芪。目前有研究發(fā)現(xiàn)紅芪中的黃酮類成分和多糖類成分可以通過促進(jìn)骨形成、抑制骨吸收和增大BMD等作用機制改善OP，但對紅芪改善OP的系統(tǒng)性總結(jié)比較少。系統(tǒng)闡釋紅芪抗OP作用及相關(guān)的機制，為紅芪改善OP作用的深入探討和有效成分的進(jìn)一步開發(fā)利用提供基礎(chǔ)參考。

Osteoporosis (OP) is a common systemic metabolic bone disease. Depending on the cause, osteoporosis can be divided into primary OP and secondary OP. Osteoporosis is mainly manifested by bone density reduction and bone destruction, which can easily lead to fractures and dysfunction. In clinical practice, chemical drugs such as calcitonin, which inhibits bone resorption, parathyroid hormone, which promotes bone formation, and Astragali Radix, Hedysari Radix-Epimedium are used to treat osteoporosis. Hedysari Radix is a tonic Chinese medicine, which has a wide range of pharmacological effects such as anti-inflammatory, immune regulation, antioxidant, prevention and treatment of diabetes complications, etc. In the past dynasties, it was mostly included under Astragali Radix. When used Astragali Radix, Hedysari Radix is better than Astragali Radix in enhancing immunity, scavenging free radical activity and anti-liver fibrosis. Current studies have found that flavonoids and polysaccharides in Hedysari Radix can improve osteoporosis by promoting bone formation, inhibiting bone absorption and increasing bone density. Therefore, this paper systematically explains the anti-osteoporosis effect of the effective ingredients of Hedysari Radix and the related mechanism, so as to provide a basic reference for the in-depth discussion of the effect of Hedysari Radix on improving osteoporosis and the further development and utilization of the effective ingredients.

R285.5

天津市制造業(yè)高質(zhì)量發(fā)展專項資金—天津天士力之驕藥業(yè)有限公司技術(shù)中心創(chuàng)新能力建設(shè)（ZZY20232088）