目的 探索糖尿病治療藥物相互作用研究的熱點(diǎn)及趨勢(shì)。方法 檢索中國(guó)學(xué)術(shù)期刊全文數(shù)據(jù)庫(kù)（CNKI）、萬(wàn)方數(shù)據(jù)庫(kù)（Wanfang Data）、維普生物醫(yī)學(xué)數(shù)據(jù)庫(kù)（VIP）和Web of Science（WOS）數(shù)據(jù)庫(kù)，收集與研究目的相關(guān)文獻(xiàn)，采用CiteSpace、VOS Viewer、COOC和Excel軟件進(jìn)行數(shù)據(jù)可視化和文獻(xiàn)計(jì)量學(xué)分析。結(jié)果 共納入82篇中文文獻(xiàn)和174篇英文文獻(xiàn)；作者分析顯示共出現(xiàn)113位核心作者；國(guó)內(nèi)發(fā)文機(jī)構(gòu)多為大學(xué)及附屬醫(yī)院，平均發(fā)文量4篇，國(guó)際發(fā)文機(jī)構(gòu)集中于跨國(guó)制藥公司，平均發(fā)文量7篇；發(fā)文量排名前3的國(guó)家分別為美國(guó)、印度、中國(guó)；排名前3的共被引文獻(xiàn)分別關(guān)注二甲雙胍和恩格列凈的藥動(dòng)學(xué)以及2型糖尿病的藥物管理共識(shí)算法；關(guān)鍵詞顯示降糖藥物出現(xiàn)頻次由高到低分別為二甲雙胍、胰島素、瑞格列奈；突現(xiàn)詞分析顯示近5年的中文突現(xiàn)詞為轉(zhuǎn)運(yùn)體、新型冠狀病毒肺炎、氯吡格雷、基因多態(tài)性、藥動(dòng)學(xué)；英文突現(xiàn)詞包括elderly、polypharmacy、drug-food interactions、hypertension。結(jié)論 二甲雙胍與其他藥物的相互作用仍是糖尿病治療藥物相互作用的研究熱點(diǎn)，基因多態(tài)性、老年人群及藥物-食物間相互作用或?qū)⒊蔀槲磥?lái)研究重點(diǎn)。

Objective To explore the research hotspots and trend of drug-drug interactions in diabetes mellitus, and to provide intuitive data reference and relevant suggestions for subsequent research. Methods CNKI, Wanfang, VIP and Web of Science (WOS) databases were searched to collect papers related to the research purpose. CiteSpace, VOS Viewer, COOC and Excel were used for data visualization and bibliometric analysis. Results A total of 82 Chinese papers and 174 English papers were included. Author analysis showed that there were 113 core authors. Most of the domestic publishing institutions were universities and affiliated hospitals, with an average of four papers, while international publishing institutions were concentrated in multinational pharmaceutical companies, with an average of seven papers. The top three countries with the highest number of articles are the United States, India and China. The top three co-citations focused on the pharmacokinetics of metformin and enaglipzin and the consensus algorithm for drug administration in type 2 diabetes respectively. Metformin, insulin and repaglinide were the frequency of hypoglycemic drugs from high to low in keywords analysis. The analysis of burst words showed that the Chinese burst words in recent 5 years were transporter, novel coronavirus pneumonia, clopidogrel, gene polymorphism and pharmacokinetics. The English burst words included elderly, polypharmacy, drug-food interactions, and hypertension. Conclusion The interaction between metformin and other drugs is still a research hotspot in the treatment of diabetes. Gene polymorphism, elderly population and drug-food interaction may become the focus of future research in the treatment of diabetes.

R969.2

中國(guó)藥品監(jiān)督管理研究會(huì)研究課題-基于多元證據(jù)體探索中成藥安全性評(píng)價(jià)方法的研究（2024-Y-Y-006）；臨床研究和成果轉(zhuǎn)化能力提升試點(diǎn)項(xiàng)目-中藥制劑研發(fā)——治療胃輕癱中藥復(fù)方佛香散（DZMG-ZJXY-23002）。