消化道腫瘤是全球疾病致死的主要原因之一，其發(fā)病率和死亡率不斷增加，嚴(yán)重危害人類的健康。由于消化道腫瘤大多發(fā)病機(jī)制復(fù)雜，轉(zhuǎn)移復(fù)發(fā)率較高，治療難度大，生存率較低，其防治工作已成為全球重大科學(xué)問題。腺苷酸活化蛋白激酶（AMPK）是調(diào)節(jié)細(xì)胞內(nèi)部能量代謝的重要感受器，而AMPK信號通路與消化道腫瘤細(xì)胞生長、增殖、凋亡、侵襲等息息相關(guān)，是抗消化道腫瘤治療的關(guān)鍵通路。中醫(yī)藥以整體觀念、辨證論治的總體理念，具有標(biāo)本兼顧、靈活配伍、高效低毒等顯著優(yōu)勢，在抗消化道腫瘤方面療效突出，廣受青睞。中藥活性成分如黃酮類、生物堿類、萜類、皂苷類、內(nèi)酯類以及中藥復(fù)方如虎七散、固本消積方、固正消癌方、左金丸以及固脾消積飲等可通過調(diào)控AMPK及其互作信號通路，誘導(dǎo)細(xì)胞自噬和凋亡、調(diào)節(jié)能量代謝、抑制有氧糖酵解、抑制上皮間質(zhì)轉(zhuǎn)化、逆轉(zhuǎn)細(xì)胞耐藥等機(jī)制，發(fā)揮抗消化道腫瘤作用。對近年來中藥治療消化道腫瘤的研究成果進(jìn)行歸納和總結(jié)，從中藥活性成分及中藥復(fù)方調(diào)控AMPK信號通路抑制消化道腫瘤進(jìn)展的角度進(jìn)行綜述，旨在為抗消化道腫瘤新藥開發(fā)提供思路和參考。

Digestive tract tumors are one of the main causes of death worldwide. Their morbidity and mortality are increasing, which seriously endangers human health and well-being. Due to the complex pathogenesis of digestive tract tumors, high recurrence rate of metastasis, difficult treatment and low survival rate, its prevention and treatment has become a major scientific problem in the world. Adenosine monophosphate activated protein kinase (AMPK) is an important receptor regulating energy metabolism in cells. AMPK signaling pathway is closely related to the growth, proliferation, apoptosis, invasion and other life activities of digestive tract tumor cells, and is a key pathway for anti-digestive tract tumor therapy. Traditional Chinese medicine, based on the holistic concept and the overall concept of syndrome differentiation and treatment, has significant advantages such as specimen consideration, flexible compatibility, high efficiency and low toxicity, and has outstanding efficacy in anti-digestive tract tumors, and is widely favored. It has been found that the active ingredients of traditional Chinese medicine such as flavonoids, alkaloids, terpenoids, saponins and lactones, as well as the compounds of traditional Chinese medicine such as Huqi Powder, Gubenxiaoji Prescription, Guzheng Xiaoyou Prescription, Zuojin Pill and Gupi Xiaoji Yin can induce autophagy and apoptosis of cells, regulate energy metabolism, inhibit aerobic glycolysis, inhibit epithelial mesenchymal transformation and reverse cell resistance by regulating AMPK and its interaction signaling pathway. To play an anti-digestive tract tumor role. In this paper, the research results on the treatment of digestive tract tumors by traditional Chinese medicine in recent years were summarized and reviewed from the perspective of regulating AMPK signaling pathway and inhibiting digestive tract tumor progression, aiming to provide ideas and references for anti-digestive tract tumors.

R979.1

國家自然科學(xué)基金資助項(xiàng)目（81804057）；河南省中醫(yī)藥科學(xué)研究專項(xiàng)課題（2022ZY2018）