目的 運(yùn)用文獻(xiàn)計(jì)量學(xué)方法系統(tǒng)解析銀杏內(nèi)酯藥理作用研究的演進(jìn)軌跡、知識(shí)結(jié)構(gòu)與前沿?zé)狳c(diǎn)，為深化藥理機(jī)制研究及臨床轉(zhuǎn)化提供循證依據(jù)。方法 基于中國學(xué)術(shù)期刊全文數(shù)據(jù)庫（CNKI）和Web of Science核心合集數(shù)據(jù)庫，系統(tǒng)檢索建庫至2025年2月20日收錄的銀杏內(nèi)酯藥理作用相關(guān)文獻(xiàn)，納入中英文文獻(xiàn)1 000篇（中文751篇、英文249篇），運(yùn)用Cite Space 6.2.R4和VOSviewer軟件進(jìn)行多維度計(jì)量分析，構(gòu)建作者、期刊、機(jī)構(gòu)、國家合作圖譜及關(guān)鍵詞共現(xiàn)、聚類、演進(jìn)圖譜。結(jié)果 研究呈現(xiàn)顯著階段性特征，年均發(fā)文量由2000年前的不足3篇增長(zhǎng)至2025年的79篇。發(fā)文期刊聚焦藥學(xué)領(lǐng)域，《中國中藥雜志》《中國藥理學(xué)通報(bào)》及Journal of Ethnopharmacology為核心載體，3刊累計(jì)發(fā)文量占比達(dá)21.3%?？蒲泻献骶W(wǎng)絡(luò)分析顯示，以肖偉（江蘇康緣藥業(yè)）、王振中（南京中醫(yī)藥大學(xué)）及謝鵬（澳門大學(xué)）為核心的跨學(xué)科團(tuán)隊(duì)形成3大研究集群。關(guān)鍵詞共現(xiàn)網(wǎng)絡(luò)識(shí)別出“神經(jīng)保護(hù)”“氧化應(yīng)激”“血腦屏障”等核心節(jié)點(diǎn)，時(shí)區(qū)圖檢測(cè)發(fā)現(xiàn)“肥胖”“認(rèn)知障礙”“衰老”“抗癌”等為新興研究熱點(diǎn)。結(jié)論 近30年來銀杏內(nèi)酯研究呈現(xiàn)從基礎(chǔ)藥理向臨床轉(zhuǎn)化、從單一機(jī)制向多組學(xué)整合的研究范式轉(zhuǎn)變。當(dāng)前熱點(diǎn)集中于神經(jīng)保護(hù)及腦卒中的治療與預(yù)后領(lǐng)域。未來重點(diǎn)攻關(guān)方向包括分子機(jī)制的精準(zhǔn)解析和銀杏內(nèi)酯遞藥系統(tǒng)的創(chuàng)新設(shè)計(jì)。

Objective Bibliometrics was used to systematically analyze the evolutionary trajectory, knowledge structure and frontier hotspots in the research on the pharmacological effects of ginkgolides, aiming to provide evidence-based references for deepening the study of pharmacological mechanisms and facilitating clinical transformation. Methods Based on the China National Knowledge Infrastructure and the Web of Science Core Collection databases, a systematic search was conducted to retrieve literature related to the pharmacological effects of ginkgolides, covering records from the inception of the databases up to February 20th, 2025. A total of 1 000 articles (751 in Chinese and 249 in English) were included in the study. Multi-dimensional bibliometrics analyses were performed by using Cite Space 6.2.R4 and VOSviewer software to construct author, periodical, institution, country collaboration maps, as well as keyword co-occurrence, clustering and evolutionary maps. Results The research showed distinct stage characteristics. The average annual number of publications increased from less than three articles before 2020 to 79 articles from 2000 to 2025. Bibliometric analysis reveals that journals focusing on pharmaceutical sciences, with China Journal of Chinese Materia Medica, Chinese Pharmacological Bulletin, and Journal of Ethnopharmacology serving as core publication platforms, collectively account for 21.3% of the total literature output. Analysis of scientific collaboration networks identified three major interdisciplinary research clusters centered around key investigators: Wei Xiao (Jiangsu Kanion Pharmaceutical), Zhenzhong Wang (Nanjing University of Chinese Medicine), and Peng Xie (University of Macau). Keyword co-occurrence network analysis pinpointed core research nodes including 'neuroprotection', 'oxidative stress', and 'blood-brain barrier'. Time-zone mapping detected emerging research hotspots such as 'obesity', 'cognitive impairment', 'aging', and 'anticancer'. Conclusion Over the past three decades, research on ginkgolides has undergone a paradigm shift, evolving from fundamental pharmacological investigations towards clinical translation and from single-mechanism studies towards integrated multi-omics approaches. Current research focus is concentrated on neuroprotection and the therapeutic and prognostic applications in stroke. Future research priorities include the precise elucidation of molecular mechanisms and the innovative design of ginkgolide drug delivery systems. This study represents the first multi-dimensional bibliometric analysis to systematically delineate the dynamic evolution of ginkgolide research, providing data-driven support for optimizing research resource allocation.

R285.5

秦巴生物資源與生態(tài)環(huán)境重點(diǎn)實(shí)驗(yàn)室（培育） “市校共建”科研專項(xiàng)（SXZC-2302）； 陜西省重點(diǎn)研發(fā)計(jì)劃項(xiàng)目（2022SF-406）