藥食同源物質(zhì)兼具“藥”與“食”的雙重特性，既有藥品的治療療效，又有食品的安全性和穩(wěn)定性，在輔助治療疾病、營養(yǎng)補充以及保健養(yǎng)生等方面發(fā)揮著重要作用。近年來，隨著人們生活水平的提高和健康意識的增強，藥食同源物質(zhì)的市場需求量持續(xù)增長。現(xiàn)階段，對于藥食同源物質(zhì)的研究大多聚焦于藥品及保健品等開發(fā)，以致力于功效挖掘。然而，對藥食同源物質(zhì)可能存在的安全風險研究相對較少，比如，部分藥食同源物質(zhì)本身含有安全風險物質(zhì)，在種植、加工等過程中還可能存在農(nóng)藥殘留、重金屬超標、真菌毒素或其他外源性殘留物污染等安全隱患問題。因此，系統(tǒng)綜述藥食同源物質(zhì)安全性風險評估的研究進展，深入剖析影響其安全性的各類因素，并進一步探討安全風險評估新技術(shù)的應(yīng)用以及未來的發(fā)展方向。旨在為藥食同源物質(zhì)精準、科學的安全性風險評估提供一定的參考，從而更好地保障公眾健康，推動藥食同源產(chǎn)業(yè)健康、可持續(xù)發(fā)展。

Medicine and food homologous substances have the dual characteristics of "medicine" and "food", both the therapeutic effect of drugs, and the safety and stability of food, and play an important role in the auxiliary treatment of diseases, nutritional supplements and health care. In recent years, with the improvement of people's living standards and the enhancement of health awareness, the market demand for medical-food homologous substances continues to grow. At present, most of the research on the homologous substances of medicine and food focuses on the development of drugs and health products, so as to devote to the efficacy mining. However, there are relatively few studies on the possible safety risks of medicine and food homologous substances. For example, some medicine and food homologous substances themselves contain safety risk substances, and there may be pesticide residues, excessive heavy metals, fungal toxins or other external residue pollution in the process of cultivation and processing. Therefore, this paper systematically reviewed the research progress of safety risk assessment of medicine and food homologous substances, deeply analyzed various factors affecting their safety, and further discussed the application and future development direction of new safety risk assessment technology. The aim is to provide a certain reference for accurate and scientific safety risk assessment of medicine and food homologous substances, so as to better protect public health and promote the healthy and sustainable development of medicine and food homologous industry.

R965.3

國家重點研發(fā)計劃項目（2022YFC2804600）；泰山學者工程資助項目（tsqn202211204）； 齊魯工業(yè)大學（山東省科學院）科教產(chǎn)融合試點工程重大創(chuàng)新類項目（2025ZDZX14）