近年來，受生活微環(huán)境及復(fù)雜因素的影響，呼吸系統(tǒng)疾病的發(fā)病率逐年上升，例如慢性阻塞性肺?。–OPD）、支氣管哮喘、肺炎、肺癌和急性呼吸窘迫綜合征（ARDS）等?；凇胺闻c大腸相表里”中醫(yī)理論，提出了“肺-腸”軸理論，“肺-腸”軸是指肺部和腸道之間微生物和/或其代謝物和免疫調(diào)節(jié)信號(hào)的相互交換?；诖死碚?，“從腸治肺”“肺腸同調(diào)”被廣泛運(yùn)用于臨床實(shí)踐。對(duì)“肺-腸”軸理論、肺部和腸道微生物群如何調(diào)節(jié)免疫應(yīng)答、“肺-腸”軸之間的免疫聯(lián)系及中藥復(fù)方通過調(diào)控“肺-腸”軸治療呼吸系統(tǒng)疾病的作用研究進(jìn)展進(jìn)行綜述，為呼吸系統(tǒng)疾病治療提供理論依據(jù)，為新藥研發(fā)開拓思路。

In recent years, due to the influence of living microenvironment and complex factors, the incidence of respiratory diseases has increased year by year, such as chronic obstructive pulmonary disease (COPD), bronchial asthma, pneumonia, lung cancer and acute respiratory distress syndrome (ARDS), which undoubtedly increases the burden of medical care. The “l(fā)ung- intestinal” axis refers to the mutual exchange of microbes and/or their metabolites and immunomodulatory signals between the lungs and the gut. Based on the traditional Chinese medicine theory of "the lung and large intestine being interior-exteriorly related," the "lung-gut" axis theory has been proposed. The "lung-gut" axis refers to the mutual exchange of microorganisms and/or their metabolites and immune-regulatory signals between the lungs and the intestines. Based on this theory, "treating lung diseases from the intestine" and "simultaneously regulating the lung and intestine" have been widely applied in clinical practice. This review summarizes the "lung-gut" axis theory, how microbial communities in the lungs and intestines regulate immune responses, the immune connections between the "lungintestinal" axis, and the research progress on the therapeutic effects of Chinese medicinal formulae in treating respiratory diseases by modulating the "lung-intestinal " axis. The aim is to provide a theoretical basis for the treatment of respiratory diseases and to explore new ideas for drug development.

R285.5

黑龍江中醫(yī)藥大學(xué)優(yōu)秀創(chuàng)新人才支持計(jì)劃（2018RCL13）