目的 探討醋酸亮丙瑞林微球聯(lián)合炔雌醇環(huán)丙孕酮片對(duì)子宮內(nèi)膜異位癥患者療效及復(fù)發(fā)率的影響。方法 選擇漢中市中心醫(yī)院2014年1月—2016年12月收治的83例子宮內(nèi)膜異位癥患者，根據(jù)隨機(jī)數(shù)字表法，分為觀察組（42例）與對(duì)照組（41例），對(duì)照組給予炔雌醇環(huán)丙孕酮片治療，觀察組在對(duì)照組基礎(chǔ)給予醋酸亮丙瑞林微球治療。兩組均治療3個(gè)月。觀察對(duì)比兩組臨床療效、治療后1年內(nèi)的復(fù)發(fā)率、治療前后的性激素水平、Kupperman評(píng)分、主觀癥狀評(píng)分及治療期間的不良反應(yīng)。結(jié)果 兩組臨床療效對(duì)比無(wú)統(tǒng)計(jì)學(xué)意義，但觀察組復(fù)發(fā)率明顯低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療前，兩組的促卵泡生成激素、促黃體生成激素、雌二醇水平、Kupperman評(píng)分及主觀癥狀評(píng)分對(duì)比無(wú)統(tǒng)計(jì)學(xué)意義；治療后，兩組以上指標(biāo)均明顯降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組明顯低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組不良反應(yīng)對(duì)比無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論 醋酸亮丙瑞林微球聯(lián)合炔雌醇環(huán)丙孕酮片治療子宮內(nèi)膜異位癥療效顯著，可降低術(shù)后復(fù)發(fā)率、雌激素，改善臨床癥狀，安全性較好。

Objective To investigate the efficacy and recurrence rate of leuprolide microspheres combined with Diane-35 in patients with endometriosis. Methods 83 cases with endometriosis from Jan. 2014 to Dec. 2016 in our hospital were chosen, who were divided into the observation group (42 cases) and control group (41 cases), the control group were given Diane-35, the observation group were given leuprolide microspheres on the base of control group, the efficacy, recurrence rate after treatment for 1 year, the sex hormone levels before and after treatment, the Kupperman score, the subjective symptom score and adverse reactions in treatment of two groups were compared. Results The efficacy of two groups had no significant different, the recurrence rate of observation group was lower than control group (P<0.05), the follicle growth hormone, luteinizing hormone and estradiol level, the Kupperman score, the subjective symptom score of two groups had no significant difference before treatment (P<0.05), the indexes after treatment of two groups were lower than before treatment, while the observation group were lower than control group (P<0.05). The adverse reactions of two groups had no significant. Conclusion Leuprolide microspheres combined with Diane-35 had significant efficacy in treatment of endometriosis, which could decrease the recurrence rate, estrogen level, improve the clinical symptoms and had great safety.