目的 探討尿激酶聯合低分子肝素（LMWH）對腦梗死患者氧化應激相關指標的影響。方法 針對2015年1月—2018年1月在西安市楊凌示范區(qū)醫(yī)院接受治療的104例腦梗死患者進行回顧性分析，將采用LMWH治療納入對照組（n=52），采用尿激酶聯合LMWH治療納入觀察組（n=52），連續(xù)治療7 d。比較兩組療效，氨基末端腦鈉肽前體（NTproBNP）、D-二聚體、氧化修飾低密度脂蛋白（Ox-LDL）、谷胱甘肽過氧物酶（GSH-Px）水平等相關因子水平及不良反應情況。結果 觀察組總有效率為90.38%，高于對照組的73.08%，差異有統(tǒng)計學意義（P<0.05）。治療前，兩組NT-proBNP、D-二聚體、Ox-LDL、GSH-Px水平均無統(tǒng)計學差異。兩組治療后NT-proBNP、D-二聚體水平均顯著下降（P<0.05）；同時觀察組治療后NT-proBNP、D-二聚體水平顯著低于對照組（P<0.05）。治療后兩組Ox-LDL水平顯著下降（P<0.05）；且觀察組顯著低于對照組（P<0.05）。治療后兩組GSH-Px水平顯著上升（P<0.05），且觀察組顯著高于對照組（P<0.05）。兩組治療后均出現皮下瘀斑等不良反應，兩組差異無統(tǒng)計學意義。結論 尿激酶聯合LMWH臨床療效顯著，可有效降低NTproBNP、D-二聚體及Ox-LDL水平，提高患者GSH-Px水平。

Objective To investigate the effect of LMWH combined with urokinase on ox-LDL and GSH-Px levels in patients with cerebral infarction.Methods A retrospective analysis of 104 patients with cerebral infarction received treatment in our hospital from January 2015 to January 2018. LMWH was used in the control group, and LMWH combined with urokinase was used in the observation group. The curative effect and the level of related factors were compared between the two groups. Results The total effective rate of the observation group was 90.38% higher than that in the control group (P<0.05). After treatment, the level of NTproBNP, D-dimer in both groups decreased significantly (P<0.05), and that in the observation group was significantly lower than that in the control group (P<0.05). And the level of Ox-LDL in the two groups decreased significantly (P<0.05), and the study group was lower than that in the control group (P<0.05). The level of GSH-Px in the two groups increased significantly after treatment, and the level of GSH-Px in the study group was higher than that in the control group (P<0.05). The adverse reactions such as subcutaneous ecchymosis appeared in both groups after treatment, but there was no significant difference between the two groups (P<0.05). Conclusion LMWH combined with urokinase the he clinical curative effect is remarkable. It can effectively reduce the level of NT-proBNP, D-dimer and ox-ldl, and increasing the level of GSH-Px.