隨著多重耐藥的病原體數(shù)量持續(xù)增加，尋找合適的抗生素替代藥物的需求日趨迫切。抗菌肽作為微生物自身的防御武器，盡管還存在毒性高、穩(wěn)定性低和生產(chǎn)成本高等限制其開發(fā)成藥物的問題需要解決，但由于其具有廣泛的抗菌譜、特殊的抗菌機制以及不容易產(chǎn)生耐藥性還是受到廣泛的關(guān)注。近年來，通過計算機輔助藥物設(shè)計、化學(xué)合成等方式來規(guī)避劣勢，開發(fā)抗菌肽藥物，有望成為新一類用于臨床的新型抗生素，并取代傳統(tǒng)的抗生素成為新的抗感染治療藥物。

As the number of muti-drug resistant pathogens continues to increase, the need to find suitable replacements is becoming more urgent. Antimicrobial peptides, as a defensive weapon of microorganisms, have received extensive attention by their wide range of antibacterial spectrum, special antibacterial mechanisms, and insusceptible to drug resistance. However,they are still exist many defects, such as high toxicity, low stability, and high production cost, which limits their development into drugs. In recent years, people have used computer-aided drug design and chemical synthesis to avoid disadvantages and develop antimicrobial peptides. This article reviews the self-limiting condition and design methods of antimicrobial peptides.

國家科技重大新藥創(chuàng)制項目（2015ZX09501004）；天津市科技計劃項目（16PTGCCX00090）