1)、β1腎上腺素受體(β1-AR)水平。取心臟測定心臟質量指數(HWI),HE染色法觀察大鼠心肌纖維排列狀況。結果 造模第5周后手術各組收縮壓較對照組顯著升高(P<0.01),驗證模型成功;給藥第2、4周,鉤藤人參合用中、高劑量組收縮壓較模型組顯著下降(P<0.05、0.01)。與模型組比較,鉤藤人參合用中、高劑量組能顯著降低心衰大鼠的HWI以及AT1、Ang Ⅱ、BNP的濃度,顯著升高β1-AR濃度(P<0.05、0.01),且呈劑量相關性。光鏡下觀察模型組心肌結構紊亂,心肌細胞排列呈波浪狀,心肌纖維斷裂嚴重;卡托普利組和人參鉤藤高劑量組可見心肌結構排列較均勻,心肌細胞形態(tài)正常,心肌纖維略有斷裂。結論 鉤藤人參合用對于降低大鼠血壓,改善大鼠心衰癥狀效果顯著,且呈劑量相關性,其中高劑量與卡托普利組效果相當。;Objective To study the effects of combination of Uncaria rhynchophylla and Panax ginseng on hypertension complicated with heart failure (HCHF) in rats. Method Rats were randomly divided into sham-operated group, model group, captopril group(0.0143 g/kg), high (Uncaria 0.9 g/kg + ginseng 1.8 g/kg), middle (Uncaria 0.45 g/kg + ginseng 0.9 g/kg), and low (Uncaria 0.225 g/kg + ginseng 0.45 g/kg) dose combination of Uncaria and ginseng groups. Rats with HCHF model was produced by abdominal aortic coarctation. After 5 weeks, assessing the success of the model through rat tail artery pressure monitoring. In the sham operation group, only abdominal aortas of rats were isolated without ligation. Enzyme-linked immunosorbent assay (ELISA) was used for determination of rat serum BNP, AngⅡ, AT1, and β1-AR. Cardiac quality index (HWI) was measured by heart test, and myocardial fiber arrangement was observed by HE staining. Results Systolic blood pressure (SBP) was significantly higher in each group than that in the control group (P<0.01) after the 5th week of model establishment, and the model was verified to be successful. At the 2nd and 4th week of administration, the SBP of the medium and high dose groups of combination of Uncaria and ginseng was significantly lower than that of the model group (P<0.05, 0.01). Compared with the model group, each dose group of combination can significantly reduce the HWI and the concentration of AT1, AngⅡ, and BNP in rats with heart failure (P<0.05), and significantly increaseβ1-AR concentration (P<0.05) in a dose-dependent manner. Under light microscope, we found that the myocardial structure of the model group was disordered, the myocardial cells arranged in a wavy manner, and the myocardial fiber was severely broken. In the captopril group and the high-dosecombination group, the myocardial structure was arranged more evenly, the myocardial cell morphology was normal, and the myocardial fiber was slightly broken. Conclusion Combination of Uncaria and ginseng has a significant effect on lowering blood pressure and improving symptoms of heart failure in rats. Among them, the high-dose combination group has the best effect, and has the same effect as the captopril group."/> 1);β1腎上腺素受體(β1-AR);心臟質量指數;Uncaria rhynchophylla (Miq.) Miq. ex Havil.;Panax ginseng C. A. Mey.;Hypertension complicated with heart failure;BNP;Ang Ⅱ;AT1;β1-AR;heart quality index"/>

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首頁 > 過刊瀏覽>2018年第41卷第12期 >2018,41(12):2183-2188. DOI:10.7501/j.issn.1674-6376.2018.12.009
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鉤藤人參合用對高血壓合并心衰大鼠模型的影響

Effects of combination of Uncaria rhynchophylla and Panax ginseng on hypertension complicated with heart failure in rats

發(fā)布日期:2018-12-17
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