目的 比較注射用雷貝拉唑鈉對不同潰瘍模型大鼠的影響。方法 采用幽門結(jié)扎法收集胃液，測定注射用雷貝拉唑鈉0.5、1.0、2.0、4.0、8.0 mg/kg對大鼠胃液酸度、胃酸總分泌量的影響。制備吲哚美辛引起的胃潰瘍模型、醋酸性胃潰瘍、大鼠反流性食管炎以及半胱胺型十二指腸潰瘍，模型動(dòng)物iv給予注射用雷貝拉唑鈉后，對潰瘍進(jìn)行評分，計(jì)算潰瘍抑制情況。結(jié)果 ①與模型組比較，注射用雷貝拉唑鈉8 mg/kg組胃液分泌量，0.5、4.0、8.0 mg/kg組胃液酸度，2、4、8 mg/kg劑量組胃酸分泌量均顯著降低（P<0.05、0.01）。②與模型組比較，0.5、1.0、2.0、4.0 mg/kg劑量組吲哚美辛引起的潰瘍得分均顯著降低（P<0.05、0.01）。③注射用雷貝拉唑鈉1 mg/kg對大鼠醋酸性胃潰瘍、反流性食管炎、半胱胺型十二指腸潰瘍抑制率分別為18.2%、37.5%和23.4%，其中對反流性食管炎的抑制作用具有顯著性差異（P<0.05）。結(jié)論 注射用雷貝拉唑鈉抑制胃酸分泌，對吲哚美辛引起胃潰瘍、反流性食管炎、十二指腸潰瘍和醋酸性胃潰瘍均有抑制作用。

Objective To compare the effect of rabeprazole sodium for injection on different ulcer models in rats. Methods Gastric acid was collected by pyloric ligation method to determine the effect of rabeprazole sodium for injection at doses of 0.5, 1.0, 2.0, 4.0, and 8.0 mg/kg on acidity and total secretion of gastric acid. Different indomethacin-induced ulcer rat models were established, including gastric ulcer model, acetic acid gastric ulcer model, reflux esophagitis model, and cysteamine duodenal ulcer model. Animal models were injected intravenously with rabeprazole sodium, and ulcer score and ulcer inhibition were then calculated. Results Compared with model group, the gastric juice secretion in the 8 mg/kg rabeprazole sodium injection group, the acidity of gastric juice in the 0.5, 4.0, and 8.0 mg/kg rabeprazole sodium groups, and the gastric acid secretion in the 2, 4, and 8 mg/kg rabeprazole sodium groups were all significantly decreased (P<0.05, 0.01). Compared with the model group, the ulcer scores in 0.5, 1.0, 2.0, and 4.0 mg/kg rabeprazole sodium groups were significantly decreased (P<0.05, 0.01). The inhibition rate of 1 mg/kg rabeprazole sodium for injection to acetic acid in rats gastric ulcer, reflux esophagitis, cysteamine duodenal ulcer respectively were 18.2%, 37.5%, and 23.4%, of which the inhibitory effect on reflux esophagitis has significant difference (P<0.05). Conclusions Rabeprazole sodium for injection has inhibitory effect on gastric acid secretion, and indomethacin-caused gastric ulcer, reflux esophagitis, duodenal ulcer, and acetic acid gastric ulcer.