目的 分析丹參注射液聯(lián)合小劑量阿司匹林治療妊娠期高血壓疾病的臨床療效及對患者血清相關(guān)指標的影響。方法 以2013年1月—2016年8月陜西省人民醫(yī)院收治的120例妊娠期高血壓疾病患者為研究對象，根據(jù)隨機數(shù)字表法分為觀察組、對照1組和對照2組，每組40例。對照1組給予常規(guī)治療，對照2組在常規(guī)治療的基礎(chǔ)上加用小劑量阿司匹林，觀察組在對照2組治療方法的基礎(chǔ)上加用丹參注射液。比較3組治療前后的血壓、尿蛋白、臨床療效和血清炎癥因子，包括腫瘤壞死因子-α（TNF-α）、白介素-6（IL-6）、血清高遷移率蛋白-1（HMGB1）水平及母嬰結(jié)局。結(jié)果 治療后，3組的收縮壓、舒張壓、24 h尿蛋白水平和孕婦血清中TNF-α、IL-6、HMGB1水平均較治療前顯著降低，同組治療前后比較差異有統(tǒng)計學意義（P<0.05）；且觀察組的以上指標均顯著低于對照1組和對照2組，差異有統(tǒng)計學意義（P<0.05）；對照2組的亦顯著低于對照1組，差異有統(tǒng)計學意義（P<0.05）。觀察組和對照2組的臨床治療總有效率均顯著高于對照1組，差異有統(tǒng)計學意義（P<0.05）；觀察組的臨床治療總有效率顯著高于對照2組，差異有統(tǒng)計學意義（P<0.05）。觀察組生產(chǎn)時胎齡顯著高于對照1組和對照2組，差異有統(tǒng)計學意義（P<0.05）；且對照2組生產(chǎn)時胎齡顯著高于對照1組，差異有統(tǒng)計學意義（P<0.05）。3組剖宮產(chǎn)率、新生兒窒息率呈降低趨勢，但兩兩比較，差異均無統(tǒng)計學意義。結(jié)論 丹參注射液聯(lián)合小劑量阿司匹林治療妊娠期高血壓疾病的臨床療效顯著，可顯著改善患者的臨床癥狀、母嬰結(jié)局，其作用機制可能與降低患者血清中TNF-α、IL-6、HMGB1水平有關(guān)。

Objectove To investigate the clinical effect of danshen injection combined with small-dosage aspirin in hypertensive disorder complicating pregnancy (HDCP) and the influence of serum related index.Methods 120 cases of patients with HDCP in our hospital were selected and divided into observation group, control group-1and control group-2,40 cases in each group. Patients in the control group-1 were treated with regular treatment, and control group-2 were treated with regular treatment and small-dosage aspirin, observation group were treated with danshen injection based on the treatment method of control group-2. Compared the blood pressure, urinary protein and clinical curative effect, serum inflammatory cytokines (tumor necrosis factor-α (TNF-α), a interleukin 6 (IL-6), serum high mobility protein 1 (HMGB1) levels and and outcomes of three groups. Results After treatment, systolic pressure, diastolic pressure, 24 h urine protein levels, pregnant women serum TNF-α, IL-6, HMGB1 levels in three group were significantly lower than before treatment (P<0.05), and the observation group were significantly lower than control group-1and control group-2 (P<0.05), the control group-2 were also significantly lower than control group-1 (P<0.05). The total effective rate, gestational week of observation group were significantly higher than control group-1and control group-2 (P<0.05), the control group-2 were also significantly higher than control group-1 (P<0.05). The gestational age of observation group were higher than group-1 and group-2 (P<0.05). The Cesarean section rate, neonatal asphyxia rate of three groups were all decreased, which had no significant differences between two groups. Conclusion Danshen Injection combined with small-dosage aspirin has remarkable clinical effect in HDCP, can significantly improve the patient's clinical symptoms and outcomes, and its mechanism may be related to reduce patients' serum TNF-a, IL-6, HMGB1 levels.