[關(guān)鍵詞]
[摘要]
目的 分析恩替卡韋與阿德福韋酯對慢性乙型肝炎的成本-效果。方法 將84例慢性乙型肝炎患者隨機(jī)分為恩替卡韋組40例和阿德福韋酯組44例治療,兩組均治療觀察12個(gè)月。運(yùn)用藥物經(jīng)濟(jì)學(xué)方法分析其成本-效果(C/E)。結(jié)果 治療3個(gè)月恩替卡韋組丙氨酸氨基轉(zhuǎn)移酶(ALT)復(fù)常率明顯高于阿德福韋酯組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05);治療6、12個(gè)月兩組ALT復(fù)常率無明顯差異。治療3、6、12個(gè)月恩替卡韋組乙型肝炎病毒(HBV)-DNA轉(zhuǎn)陰率均明顯高于阿德福韋酯組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療3、6、12個(gè)月恩替卡韋組乙型肝炎E抗原(HBeAg)轉(zhuǎn)陰率均明顯高于阿德福韋酯組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療12個(gè)月恩替卡韋組的ALT復(fù)常率、HBV-DNA轉(zhuǎn)陰率、HBeAg轉(zhuǎn)陰率的C/E分別為273.3、352.6、911.0,阿德福韋酯組分別為194.2、328.6、908.6。將阿德福韋酯組作為參照,恩替卡韋組HBV-DNA轉(zhuǎn)陰率及HBeAg轉(zhuǎn)陰率的增量成本-效果(△C/△E)分別為129.7、182.1。結(jié)論 從短期看,阿德福韋酯治療慢性乙型肝炎的療效尚可,藥物經(jīng)濟(jì)學(xué)價(jià)值較高,而恩替卡韋雖然療效更好,但療效與成本尚未達(dá)到理想的平衡。
[Key word]
[Abstract]
Objective To analysis the cost-effectiveness analysis of different drugs in patients with chronic hepatitis B.Methods 84 patients with chronic hepatitis B were randomly divided into Entecavir (ETV) group with 40 cases and Adefovir dipivoxil (ADV) group with 44 cases, and pharmacoeconomic analysis of cost effectiveness (C/E) were conducted.Results ALT complex rate, HBVDNA negative rate and HBeAg negative rate after 12 months treatment of the ETV group were 100.0%, 77.5% and 30.0%, and of the ADV group were 100.0%, 59.1% and 13.6%, the HBV-DNA negative rate and HBeAg negative rate between the two groups were statistical significant (P<0.05). The C/E of ALT complex rate, HBV-DNA negative rate and HBeAg negative rate of the ETV group were 273.3,352.6 and 911.0, and of the ADV group were 194.2,328.6 and 908.6.ADV group as a reference, the △C/△E of HBV-DNA negative rate and HBeAg negative rate of the ETV group were 129.7 and 182.1.Conclusions In the short term, Adefovir dipivoxil in the treatment of chronic hepatitis B is acceptable, the value of pharmacoeconomics is high, but whether it is the ideal long-term antiviral program remains to be studied.
[中圖分類號(hào)]
[基金項(xiàng)目]