目的 探討甘味顆粒抗抑郁癥的分子機(jī)制。方法 借助中藥整合藥理學(xué)平臺(tái)（TCMIP），檢索甘味顆粒所含的化學(xué)成分信息，建立甘味顆粒作用的潛在靶標(biāo)和疾病靶標(biāo)之間的相互作用網(wǎng)絡(luò)；富集計(jì)算核心靶標(biāo)，進(jìn)行基因功能分析和通路分析，再進(jìn)一步構(gòu)建"中藥材-化學(xué)成分-核心靶標(biāo)-關(guān)鍵通路"多維關(guān)系網(wǎng)絡(luò)。結(jié)果 對(duì)甘味顆粒預(yù)測(cè)共得到65個(gè)活性成分，涉及33個(gè)關(guān)鍵靶標(biāo)，甘味顆粒通過(guò)作用于Rap1信號(hào)通路、神經(jīng)系統(tǒng)、雌激素信號(hào)通路、促性腺激素釋放激素信號(hào)通路、神經(jīng)膠質(zhì)瘤、甲狀腺激素信號(hào)通路、血小板激活、谷氨酸能突觸、心肌細(xì)胞腎上腺素能信號(hào)傳導(dǎo)、循環(huán)系統(tǒng)等相關(guān)生物過(guò)程和代謝通路發(fā)揮治療抑郁癥的作用。結(jié)論 初步揭示了甘味顆粒抗抑郁的潛在活性成分及其可能的作用機(jī)制。

Objective To explore the molecular mechanism of Ganwei Granules on depressive disorder. Methods Based on the platform of Integrative Pharmacology of Traditional Chinese Medicine (www.tcmip.cn), the chemical composition information in Ganwei Granules were retrieved, an interaction network between potential targets and disease targets of Ganwei Granules was established. Then enrichment calculation of core targets for gene function analysis and pathway analysis was carried out to further construct the multi-dimensional relationship network of "Chinese medicinal materials-chemical composition-core target-key pathway". Results A total of 65 predicted active ingredients of Ganwei Granules interacted with 33 key targets related to depression. The of antidepression mechanism of Ganwei Granules might be associated with Rap1 signaling pathway, nervous system, estrogen signaling pathway, gonadotropin releasing hormone signaling pathway, glioma, thyroid hormone signaling pathway, platelet activation, glutamatergic synapse, adrenergic signal transduction in cardiac myocytes, circulatory system and other pathways. Conclusion This research may reveal the potential active ingredients of Ganwei Granules in treatment of depression and its possible mechanism.