目的 研究鹽酸曲美他嗪膠囊聯(lián)合阿托伐他汀鈣片對冠心病患者血小板活化功能和血管內(nèi)皮功能的影響。方法 選擇2015年1月-2017年12月平頂山市第二人民醫(yī)院收治的153例冠心病患者，隨機(jī)分為兩組。對照組口服阿托伐他汀鈣片進(jìn)行治療，觀察組在對照組的基礎(chǔ)上聯(lián)合口服鹽酸曲美他嗪膠囊進(jìn)行治療。兩組均治療90 d。比較兩組臨床療效、治療前后的血小板活化功能和血管內(nèi)皮功能指標(biāo)改變情況。結(jié)果 觀察組的有效率明顯高于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。兩組治療后的α顆粒膜蛋白140（GMP-140）以及血管性假性血友病因子（vWF）水平均明顯降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；治療后觀察組的GMP-140、vWF水平明顯低于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。兩組治療后的血漿內(nèi)皮素水平明顯降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；治療后觀察組明顯低于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 鹽酸曲美他嗪膠囊聯(lián)合阿托伐他汀鈣片治療冠心病患者可以有效發(fā)揮抑制血小板活化、改善內(nèi)皮細(xì)胞損傷的效果。

Objective To investigate the clinical effect of Atorvastatin Calcium Tablets combined with Trimetazidine Hydrochloride Capsules on platelet activation and endothelial function in patients with coronary heart disease. Methods Selected 153 cases of patients with coronary heart disease who were treated in our hospital from January 2015 to December 2017, divided into two groups randomly. The control group oral Atorvastatin Calcium Tablets, observation group combined with Trimetazidine Hydrochloride Capsules. Platelet activation and vascular endothelial function in two groups before and after treatment were compared.Results The effective rate of the observation group was significantly higher than control group (P<0.05). After treatment, the levels of GMP-140 and vWF were significantly decreased (P<0.05), and the levels of GMP-140 and vWF in the observation group were significantly lower than control group (P<0.05). The plasma endothelin level of the two groups decreased significantly after treatment (P<0.05), and the observation group was more significant (P<0.05). Conclusion s Atorvastatin Calcium Tablets combined with Trimetazidine Hydrochloride Capsules can effectively inhibit platelet activation and improve endothelial cell injury in patients with coronary heart disease.