目的 探究舍曲林聯(lián)合丁苯酞在改善急性腦梗死患者認知功能及對其血清指標的影響。方法 選取2015年1月-2017年1月于佛山市第二人民醫(yī)院進行治療的75例急性腦梗死患者為研究對象，按照隨機數(shù)字表法將其分為聯(lián)合組（36例）與對照組（39例），其中對照組在常規(guī)治療的基礎上使用丁苯酞軟膠囊進行治療，聯(lián)合組在對照組基礎上加用舍曲林，兩組患者治療時間均為4周。治療結束后對兩組的治療有效率進行評估對比，并對兩組的血管內(nèi)皮生長因子（VEGF）、白細胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）水平進行檢測，使用美國國立衛(wèi)生院研究院神經(jīng)功能缺損量表（NIHSS）對兩組患者治療前后的神經(jīng)缺損情況進行評定，使用蒙特利爾認知評估量表（MoCA）對兩組患者治療前后的認知功能進行評定。結果 聯(lián)合組治療有效率為91.67%，高于對照組的64.10%，對比差異具有統(tǒng)計學意義（P<0.05）。兩組治療前VEGF、IL-6、TNF-α水平對比差異不具有統(tǒng)計學意義；治療后，兩組VEGF水平均升高，IL-6、TNF-α水平均降低，組內(nèi)差異有統(tǒng)計學意義（P<0.05）；治療后聯(lián)合組VEGF水平高于對照組，IL-6、TNF-α水平低于對照組，差異具有統(tǒng)計學意義（P<0.05）。治療前兩組NIHSS、MoCA評分差異不具有統(tǒng)計學意義；治療后兩組NIHSS評分均降低，MoCA評分均升高，組內(nèi)差異有統(tǒng)計學意義（P<0.05）；治療后聯(lián)合組NIHSS評分低于對照組，MoCA評分高于對照組，差異具有統(tǒng)計學意義（P<0.05）。結論 舍曲林聯(lián)合丁苯酞用于急性腦梗死的治療，能夠提高患者治療后的認知功能，可能與影響急性腦梗死患者的血清因子水平有關。

Objective To investigate the effect of butylphenol combined with sertraline on improving cognitive function and serum indexes in patients with acute cerebral infarction. Methods Seventy-five patients with cerebral infarction who were treated in our hospital from January 2015 to January 2017 were selected as experimental subjects and divided into combination group (36 cases) and control group (39 cases) according to the random number table method. The control group was treated with butylphenol on the basis of routine treatment. The combination group was given sertraline on the basis of the control group. The treatment time of both groups was 4 weeks. After the intervention, the treatment efficiency was evaluated The levels of vascular endothelial growth factor (VEGF), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the two groups were measured by using the National Institutes of Health, The NIHSS was used to assess the neurological deficits in both groups before and after treatment. Finally, the Cognitive Function before and after treatment in both groups was assessed by using the Montreal Cognitive Assessment Scale (MoCA).Results The effective rate of combination group was 91.67, which was higher than that of control group (64.10%), the difference was statistically significant (P<0.05). There was no significant difference in the levels of VEGF, IL-6 and TNF-(P<0.05). There was no statistical difference in the NIHSS and MoCA scores between the two groups before treatment (P<0.05), the level of VEGF in the combination group was significantly higher than that in the control group, the levels of IL-6 and TNF-α were lower than those in the control group (P<0.05). The scores of NIHSS in the combination group were lower than those in the control group after treatment, and the MoCA score was higher than that in the control group (P<0.05). Conclusion s Butylphthalide combined with sertraline in patients with cerebral infarction can significantly improve their cognitive function, while improving their serum factor levels.