自乳化藥物遞送系統(tǒng)具有制備簡單、減少胃腸道刺激、改善藥物口服吸收、提高藥物穩(wěn)定性及生物利用度等優(yōu)勢，常作為解決疏水性和親脂性藥物口服吸收的重要策略。根據(jù)近年國內(nèi)外相關(guān)文獻，歸納整理自乳化釋藥系統(tǒng)的處方篩選與優(yōu)化、質(zhì)量評價、制劑新技術(shù)等內(nèi)容；分析已上市藥物應(yīng)用情況，探究其發(fā)展瓶頸，以期為進一步深入探究自乳化遞藥系統(tǒng)的發(fā)展，自微乳制劑的上市應(yīng)用提供有價值參考。

Self-emulsifying drug delivery system has the advantages of simple preparation,reduced gastrointestinal irritation,improved oral absorption,improved drug stability and bioavailability,which is often used as an important strategy to solve the oral absorption of hydrophobic and lipophilic drugs.According to the relevant literatures at domestic and foreign in recent years,the optimization of formulation,quality evaluation,and the new technology of preparations of self-emulsifying drug release system were summarized to analyze the application situation of listed drugs and explore its development bottleneck.It is expected to provide valuable reference for further research on the development of self-emulsifying drug delivery system and the marketing application of self-microemulsion preparation.

國家教育部春暉計劃（Z2008-1-15016）；黑龍江省自然科學(xué)基金（H2016057，H2017066）；黑龍江省教育廳骨干教師基金（1251G058）；黑龍江中醫(yī)藥大學(xué)“優(yōu)秀創(chuàng)新人才支持計劃”項目（2012）