+值顯著增加,CD8+值顯著降低,與治療前對(duì)比差異顯著(P<0.05);對(duì)照組治療前后對(duì)比無顯著差異。兩組治療后的血清腫瘤壞死因子-α(TNF-α)與白介素-6(IL-6)值顯著低于治療前(P<0.05);且治療后觀察組上述值也顯著低于對(duì)照組(P<0.05)。結(jié)論 霧化吸入兩性霉素能有效預(yù)防ICU住院患兒獲得性真菌性肺炎的發(fā)生,且不會(huì)增加不良反應(yīng)的發(fā)生,其作用機(jī)制可能與增強(qiáng)機(jī)體免疫功能與抑制炎癥因子的釋放有關(guān)。;Objective To explore the values of inhalation of amphotericin in the prevention of acquired fungal pneumonia in ICU hospitalized children.Methods Used the summary and review research method,from September 2015 to January 2018,180 cases of ICU hospitalized children in the Children's Hospital of Zhengzhou University were selected and were divided into the observation group of 100 cases and 80 cases in the control group accorded to the different treatment methods,the control group were given routine treatment,the observation group were given inhalation of amphotericin therapy based on the control group treatment,the acquired fungal pneumonia incidence and prognosis in the two groups were recorded.Results The acquired fungal pneumonia in the observation group and the control group were 0% and 7% respectively,and the observation group were significantly lower than the control group (P<0.05).The incidence of complications such as fever,digestive system abnormality and electrolyte imbalance during the treatment of the two groups were 9% and 8.8% respectively,and there were no significant difference compared between the two groups.The CD4+ value of the observation group were significantly increased after treatment,and the CD8+ value were significantly decreased (P<0.05).There were no significant difference between the control group before and after treatment (P<0.05).The value of serum TNF-α and IL-6 in the observation group and the control group were significantly lower than that before the treatment (P<0.05),and the above values in the observation group were also significantly lower than those in the control group (P<0.05).Conclusion The atomization inhalation amphotericin can effectively prevent the occurrence of acquired fungal pneumonia in ICU hospitalized children,and it will not increase the incidence of adverse reactions.Its mechanism may be related to enhance the immune function of the body and inhibite the release of inflammatory factors."/>