[關鍵詞]
[摘要]
高三尖杉酯堿存在于三尖杉屬植物,2012年被美國FDA批準上市用于慢性粒細胞白血病,引起醫(yī)藥工作者更廣泛關注。目前,在其原料藥的來源途徑、理化性質、抗癌活性、臨床應用、作用機制等方面已積累了較大量文獻,現(xiàn)有綜述主要集中在抗癌機制及在血液病應用方面,對藥物研發(fā)有重要影響的原料藥來源、理化性質、質量控制、構效關系等少有梳理。本文以"homoharringtonine"、"Cephalotaxine"、"Tissue culture"、"SAR"等為中、英文主題詞,查詢Elsevier及cnki、vip、Wanfang等數(shù)據(jù)庫,歸納整理上述內(nèi)容,以期為深入開發(fā)奠定基礎。
[Key word]
[Abstract]
Homoharringtonine exists in the genus Cephalotaxine,approved by FDA for chronic myeloid leukemia in 2012,causing wider concern for pharmaceutical workers.At present,a large number of literatures have been accumulated on the origin of its raw material drugs,physicochemical properties,anticancer activity,clinical application,mechanism of action and so forther.The current review focuses on anticancer mechanisms and applications in hematologic diseases,The origin of raw material drugs,physical and chemical properties,quality control and structure-activity relationship which have important influence on drug research and development are rarely combed.This artical takes "homoharringtonine","Cephalotaxine" "Tissue culture","SAR"as the Chinese and English subject words,queries databases including Elsevier and CNKI,vip,Wanfangand so forther,summarize the above contents,in order to lay the foundation for further development.
[中圖分類號]
[基金項目]
黑龍江省自然科學基金(H2016057,H2017066);黑龍江中醫(yī)藥大學"優(yōu)秀創(chuàng)新人才支持計劃"項目(2012);國家教育部春暉計劃(Z2008-1-15016);黑龍江省教育廳骨干教師基金(1251 G058)