目的 建立ICP-MS法測(cè)定茯苓中砷（As）、鈹（Be）、鎘（Cd）、鈷（Co）、銅（Cu）、錳（Mn）、鉬（Mo）、鎳（Ni）、鉛（Pb）、銻（Sb）、硒（Se）、鈦（Ti）、鉈（TI）、釩（V）、鉻（Cr）、鋅（Zn）、汞（Hg）共17種金屬元素的含量，并對(duì)不同產(chǎn)地的11批茯苓的金屬元素含量進(jìn)行評(píng)價(jià)。為中藥材生產(chǎn)中的質(zhì)量控制和臨床上的安全用藥提供了科學(xué)依據(jù)。方法 樣品經(jīng)微波消解處理后，以Se、Y、In、In-1、Bi為內(nèi)標(biāo)，采用ICP-MS法同時(shí)進(jìn)行測(cè)定。結(jié)果 對(duì)于各測(cè)定元素，標(biāo)準(zhǔn)曲線的相關(guān)系數(shù)r>0.998，回收率在88.0%~107.3%，RSD值在0.1%~11.0%。結(jié)論 該方法簡(jiǎn)便、快速、準(zhǔn)確，可用于茯苓中藥材中17種元素的含量測(cè)定。

Objective The Chinese herbal medicine Poria as the research object, the determination of arsenic in Poria ICP-MS method (As), beryllium (Be), cadmium (Cd), cobalt (Co), copper (Cu), manganese (Mn), molybdenum (Mo), nickel (Ni), lead (Pb), antimony (Sb), selenium (Se), titanium (Ti), thallium (TI) and vanadium (V), chromium (Cr), zinc (Zn), mercury (Hg) content of 17 kinds of metal elements, and the content of metal elements in different places of the 11 batch of Poria was evaluated. It provides a scientific basis for quality control and clinical safety in the production of Chinese medicinal materials. Methods An Inductivety Coupled Plasma-Mass Spectrometry method with Microwave-Assisted Digestion was developed with Se, Y, In, In-1 and Bi as internal standard. Results For the determination of each element, the correlation coefficients were better than 0.998 0-0.999 9, the recovery values ranged from 88.0% to 107.3%, and the RSD values ranged from 0.1% to 11.0%.Conclusion The method is simple, rapid and accurate, and can be used for the determination of 17 elements in Chinese medicinal materials.