目的 探討地奧心血康軟膠囊對冠心病介入術(shù)后心絞痛及血清脂質(zhì)過氧化物的影響。方法 按隨機數(shù)字表法將2015年12月-2017年8月行冠狀動脈介入術(shù)治療的88例冠心病患者分為觀察組和對照組，每組44例。對照組患者接受常規(guī)綜合治療，觀察組在常規(guī)綜合治療基礎(chǔ)上使用地奧心血康軟膠囊治療，3次/d，2粒/次。兩組均連續(xù)治療3個月。比較兩組生命質(zhì)量[西雅圖心絞痛量表（SAQ）評分]、血清脂質(zhì)過氧化物[超氧化物歧化酶（SOD）、丙二醛（MDA）]、超敏C反應(yīng)蛋白（hs-CRP）、心絞痛和用藥安全性。結(jié)果 治療后，兩組心絞痛穩(wěn)定狀態(tài)、軀體活動受限、治療滿意程度、心絞痛發(fā)作情況、疾病認識程度評分均較治療前明顯升高，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組心絞痛穩(wěn)定狀態(tài)、軀體活動受限、心絞痛發(fā)作情況評分和總分均高于對照組，差異具有統(tǒng)計學(xué)意義（P<0.05）；兩組治療滿意程度和疾病認知程度評分比較，差異無統(tǒng)計學(xué)意義。治療后，兩組MDA水平均降低，SOD水平均升高，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；觀察組MDA水平低于對照組，SOD水平高于對照組，差異具有統(tǒng)計學(xué)意義（P<0.05）。觀察組心絞痛治療有效率為90.91%，高于對照組的72.73%，差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后兩組hs-CRP水平均明顯降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組hs-CRP水平低于對照組，差異具有統(tǒng)計學(xué)意義（P<0.05）。兩組患者治療期間均未出現(xiàn)明顯的不良反應(yīng)。結(jié)論 地奧心血康軟膠囊能緩解冠心病介入術(shù)后心絞痛癥狀，改善血清脂質(zhì)過氧化物水平，降低炎性反應(yīng)，提高患者生命質(zhì)量。

Objective To investigate the effect of Di'ao Xinxuekang Soft Capsules on postoperative angina pectoris and serum lipid peroxide in coronary heart disease (CHD) patients with percutaneous coronary intervention (PCI). Methods A Total of 88 CHD patients treated with PCI in the hospital from December 2015 to August 2017 were divided into two groups according to random number table, with 44 cases in each group. Control group was given routine comprehensive treatment, while observation group was treated with Di'ao Xinxuekang soft capsules based on control group, with two pills three times a day. And the two groups were treated for three months. The living quality[Seattle angina questionnaire (SAQ)], serum lipid peroxide[superoxide dismutase (SOD), malondialdehyde (MDA)], hypersensitive C-reactive protein (hs-CRP), angina pectoris, safety of medication were compared between the two groups.Results After treatment, the scores of anginal stability, physical limitation, treatment satisfaction, attacks of angina pectoris, illness cognition in the two groups were higher than those before treatment, and there was statistical difference in the same group before and after treatment (P<0.05); The scores of anginal stability, physical limitation, attacks of angina pectoris and total scores in observation group were higher than those in control group (P<0.05); There was no statistical difference in the scores of treatment satisfaction and illness cognition between the two groups. After treatment, the MDA levels of the two groups decreased and SOD levels increased, and there was statistical difference in the same group before and after treatment (P<0.05); The level of MDA in observation group was lower than that in control group, while the level of SOD in observation group was higher than that in control group (P<0.05). The curative effective rate of angina pectoris in observation group[90.91% (40/44)] was higher than that in control group[72.73% (32/44)] (P<0.05). After treatment, the levels of hs-CRP in the two groups significantly decreased, and there was statistical difference in the same group before and after treatment (P<0.05). The level of hs-CRP in observation group was lower than that in control group (P<0.05). There were no obvious adverse reactions in the two groups during treatment. Conclusion Di'ao Xinxuekang Soft Capsules for CHD) patients with PCI can effectively relieve postoperative angina pectoris, improve the level of serum lipid peroxide, decrease the inflammatory response and increase patients' living quality.

南充市基層醫(yī)療機構(gòu)合理用藥現(xiàn)狀及政策研究（項目編號：SWFZ17-Y-31）