目的 研究芪參益氣滴丸聯(lián)合替格瑞洛對(duì)冠心病患者血漿內(nèi)脂素水平和血清氧化應(yīng)激標(biāo)志物的影響。方法 選擇2015年1月-2017年1月西寧市第一人民醫(yī)院收治的120例冠心病患者，隨機(jī)分為兩組。對(duì)照組口服替格瑞洛治療，觀察組聯(lián)合服用芪參益氣滴丸。兩組均治療4周。比較兩組治療前后的血漿內(nèi)脂素水平和血清氧化應(yīng)激水平的改變情況。結(jié)果 觀察組的有效率明顯高于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組的超氧化物歧化酶（SOD）、晚期糖基化終末產(chǎn)物（AGEs）、丙二醛（MDA）以及晚期蛋白質(zhì)氧化產(chǎn)物（AOPP）等氧化應(yīng)激指標(biāo)均明顯改善，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組明顯優(yōu)于對(duì)照組，組間差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組的血漿內(nèi)臟脂肪素（visfatin）水平均明顯降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組明顯低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。觀察組1年后發(fā)生心肌梗死2例，心力衰竭1例，心絞痛2例，消化道出血3例，冠脈支架再狹窄1例，再次血運(yùn)重建2例，總發(fā)生率為18.33%，明顯低于對(duì)照組的31.67%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 芪參益氣滴丸聯(lián)合替格瑞洛對(duì)冠心病患者的治療效果明顯優(yōu)于單用西藥替格瑞洛，不僅能有效改善患者的血漿內(nèi)脂素水平和氧化應(yīng)激狀態(tài)，還有助于改善預(yù)后情況。

Objective To study the effect of Qishen Yiqi Dripping Pills combined with Ticagrelor on plasma visfatin level and serum oxidative stress markers in patients with coronary heart disease. Methods A total of 120 cases of patients with coronary heart disease who were treated in our hospital from January 2015 to January 2017, were divided into two groups randomly. The control group was treated with the oral administration of Ticagrelor and the observation group was given Qishen Yiqi Dripping Pills. Plasma visfatin levels and serum oxidative stress levels were compared between the two groups before and after treatment. Results The effective rate of the observation group was significantly higher than control group (P<0.05). After treatment, the oxidative stress indexes of SOD, AGEs, MDA and AOPP in the two groups were significantly improved (P<0.05), and the observation group was significantly better than the control group (P<0.05). The plasma visfatin levels of the two groups were significantly lower (P<0.05), and the observation group was lower (P<0.05). The total incidence of myocardial infarction, heart failure, angina, gastrointestinal bleeding, coronary stent restenosis and re revascularization after 1 years in the observation group was significantly lower than control group (P<0.05). Conclusion The effect of Qishen Yiqi Dropping Pills combined with Ticagrelor on patients with coronary heart disease is obviously better. It can not only improve the plasma lipoprotein level and oxidative stress state of the patients, but also improve the prognosis.