目的 研究礞石滾痰丸聯(lián)合哌羅匹隆對(duì)精神分裂癥患者血清生化指標(biāo)的影響。方法 選擇2015年1月-2017年12月南陽(yáng)市第四人民醫(yī)院收治的300例精神分裂癥患者，隨機(jī)分為兩組。對(duì)照組單純口服哌羅匹隆，觀察組聯(lián)合口服礞石滾痰丸。兩組均治療6周。比較兩組治療前后的陽(yáng)性和陰性癥狀量表評(píng)分（PANSS）和血清生化指標(biāo)改變情況。結(jié)果 與對(duì)照組臨床有效率78.00%比較，觀察組臨床有效率92.67%顯著高于對(duì)照組（P<0.05）。治療后，兩組PANSS評(píng)分均顯著降低（P<0.05）；且觀察組PANSS評(píng)分顯著低于對(duì)照組（P<0.05）。治療后，兩組血清皮質(zhì)醇（Cor）、神經(jīng)生長(zhǎng)因子（NGF）、腦源性神經(jīng)營(yíng)養(yǎng)因子（BDNF）水平均顯著降低（P<0.05），血清5-羥色胺（5-HT）水平均顯著升高（P<0.05）；且觀察組血清Cor、NGF、BDNF水平顯著低于對(duì)照組，5-HT水平顯著高于對(duì)照組（P<0.05）。對(duì)照組不良反應(yīng)的發(fā)生率為36.0%，觀察組為35.3%，對(duì)比無(wú)明顯的差異。結(jié)論 礞石滾痰丸聯(lián)合哌羅匹隆對(duì)精神分裂癥患者具有較為顯著的治療效果，其作用機(jī)制可能與降低血清Cor、NGF、BDNF水平，提高血清5-HT水平有關(guān)。

Objective To study the effect of Mengshi Guntan Wan combined with perperone on serum biochemical indexes in patients with schizophrenia. The control group was given oral Pa Rossi Dean alone, and the observation group was given oral Morinda officinalis oligosaccharide capsule. The PANSS scores and serum biochemical indexes of the two groups before and after treatment were compared. Results The effective rate of the observation group was significantly higher than control group (P<0.05). The PANSS scores of the two groups after treatment were significantly lower (P<0.05), and the observation group was more obvious (P<0.05). After treatment, the levels of Cor, NGF and BDNF in serum of the two groups were significantly decreased (P<0.05), and the levels of serum 5-HT were significantly increased (P<0.05), especially in the observation group (P<0.05). The incidence of adverse reactions in the control group was 36.0%, which was 35.3% in the observation group, and there was no significant difference between the two groups. Conclusion Mengshi Guntan Wan combined with perperone has a significant therapeutic effect on schizophrenia. Its mechanism may be related to the reduction of serum Cor, NGF, BDNF levels and the increase of serum 5-HT levels.