目的 探討百令膠囊聯(lián)合醋酸潑尼松對腎病綜合征患者腎功能及脂質代謝紊亂的影響。方法 按隨機數(shù)字表法將2016年2月-2017年5月接診的96例腎病綜合征患者分為對照組和觀察組，每組48例。對照組采用醋酸潑尼松治療，觀察組在此基礎上給予百令膠囊。連續(xù)用藥6個月后，比較兩組肝功能[血尿素氮（BUN）、血漿白蛋白（ALB）、血肌酐（SCr）]、脂質代謝[高密度脂蛋白膽固醇（HDL-C）、三酰甘油（TG）、低密度脂蛋白膽固醇（LDL-C）、膽固醇（TC）]、24 h尿蛋白水平以及臨床療效。結果 治療后，兩組BUN、ALB、SCr水平較治療前具有顯著改善（P<0.05），且觀察組BUN、SCr水平低于對照組，ALB水平高于對照組，差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組HDL-C水平顯著升高，LDL-C、TG、TC水平均顯著降低（P<0.05）；且觀察組HDL-C水平高于對照組，LDL-C、TG、TC水平均低于對照組，差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組24 h尿蛋白水平均明顯下降（P<0.05），且觀察組24 h尿蛋白水平低于對照組，差異具有統(tǒng)計學意義（P<0.05）。觀察組治療總有效率為95.83%，明顯高于對照組的81.25%，差異具有統(tǒng)計學意義（P<0.05）。結論 對腎病綜合征患者采用百令膠囊、醋酸潑尼松聯(lián)合治療，能改善腎功能和脂質代謝紊亂，降低24 h尿蛋白水平，提高臨床療效。

Objective To investigate the effect of Corbrin capsules combined with prednisone acetate on renal function and lipid metabolism disorder in patients with nephrotic syndrome (NS).Methods 96 NS patients admitted into our hospital from February 2016 to May 2017 were divided into two groups by random number table, 48 cases in each group. Control group was given prednisone acetate, while experimental group was treated with Corbrin capsules based on control group. After six-month treatment, the liver function[blood urea nitrogen (BUN), albumin (ALB), serum creatinin (SCr)], lipid metabolism[high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC)], 24h urinary protein level and clinical efficacy were compared between the two groups.Results The levels of BUN and SCr in experimental group were lower than those in control group, while the level of ALB was higher than control group (P<0.05). The levels of TG, TC, LDL-C in experimental group were lower than those in control group, while the level of HDL-C was higher than control group (P<0.05). The 24 h urinary protein of experimental group[(1.46 ±1.05) g/24 h] was lower than control group[(2.18 ±1.22) g/24 h] (P<0.05). The total effective rate of experimental group (95.83%) was higher than control group (81.25%) (P<0.05).Conclusion Corbrin capsules combined with prednisone acetate in treatment of NS can effectively improve renal function and lipid metabolism disorder, decrease the level of 24 h urinary protein and increase clinical efficacy.