目的 研究丙種球蛋白聯(lián)合阿糖腺苷對(duì)小兒病毒性腦炎患者血清丙二醛及超氧化物歧化酶水平的影響。方法 選擇2014年1月-2017年12月崇州市婦幼保健院的102例小兒病毒性腦炎患者，隨機(jī)分為兩組。對(duì)照組靜脈滴注阿糖腺苷，每次7 mg，每天1次；觀察組聯(lián)合靜脈注射丙種球蛋白，每天1 g/kg，均治療5 d，對(duì)比兩組療效。結(jié)果 觀察組的總有效率為92.16%，明顯高于對(duì)照組的76.47%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。觀察組的嘔吐消失時(shí)間、退熱時(shí)間、頭痛消失時(shí)間、意識(shí)清醒時(shí)間以及驚厥消失時(shí)間均顯著短于對(duì)照組（P<0.05）。治療后，兩組患者的CD8⁺、CD4⁺、CD3⁺和CD4⁺/CD8⁺等細(xì)胞免疫功能指標(biāo)均較治療前顯著升高（P<0.05）；且觀察組CD3⁺、CD4⁺和CD4⁺/CD8⁺顯著高于對(duì)照組（P<0.05）。治療后，兩組患者的血清丙二醛水平均顯著降低，超氧化物歧化酶水平均顯著升高（P<0.05）；且觀察組顯著優(yōu)于對(duì)照組（P<0.05）。結(jié)論 丙種球蛋白聯(lián)合阿糖腺苷可以顯著改善小兒病毒性腦炎的癥狀，增強(qiáng)免疫功能，改善血清丙二醛及超氧化物歧化酶水平，減輕氧化應(yīng)激反應(yīng)，值得臨床推薦。

Objective To investigate the clinical effect of gamma globulin combined with adenosine on serum malondialdehyde and superoxide dismutase levels in children with viral encephalitis. Methods Selected 102 cases of children with viral encephalitis who were treated in our hospital from January 2014 to December 2017, divided into two groups randomly. The control group was intravenously injected with aradenosine, and the observation group was given intravenous immunoglobulin. Compare the efficacy of the two groups. Results The all effective rate of the observation group was significantly higher than control group (P<0.05). The vomiting time, fever time, headache disappearance time, consciousness recovery time and convulsion disappear time in the observation group were significantly shorter than those in the control group (P<0.05). After treatment, the levels of CD4⁺/CD8⁺, CD8⁺, CD3⁺ and CD4⁺in two groups were significantly higher than those before treatment (P<0.05), and the CD3⁺ and CD4⁺, CD4⁺/CD8⁺ in observation groups were more significantly higher than those in control group (P<0.05). The serum malondialdehyde decreased significantly, superoxide dismutase levels were significantly increased, and the observation group was more significant (P<0.05). Conclusion The combination of gamma globulin and adenosine can significantly improve the symptoms of viral encephalitis in children, enhance the immune function, improve the level of serum malondialdehyde and superoxide dismutase, and alleviate the oxidative stress.