目的 探討阿莫西林聯(lián)合奧美拉唑治療消化性潰瘍合并上消化道出血的臨床治療效果。方法 選取2017年3月-2018年3月在上海市嘉定區(qū)安亭醫(yī)院收治的消化性潰瘍合并上消化道出血患者80例，采用隨機數(shù)字法分為觀察組（40例）和對照組（40例），對照組患者僅給予奧美拉唑進行治療，觀察組患者在對照組基礎(chǔ)上聯(lián)合阿莫西林治療，治療療程均為14 d。比較兩組患者的臨床基線數(shù)據(jù)、治療有效率和不良反應發(fā)生率，及住院時間、出血量、潛血轉(zhuǎn)陰時間。結(jié)果 觀察組患者的治療有效率為87.50%，對照組患者的治療有效率為65.00%，差異具有統(tǒng)計學意義（P<0.05）。觀察組患者不良反應發(fā)生率為10.00%，對照組患者不良反應發(fā)生率為27.50%，差異具有統(tǒng)計學意義（P<0.05）。與對照組相比，觀察組患者的住院時間及潛血轉(zhuǎn)陰時間均顯著縮短，而出血量顯著減少，差異具有統(tǒng)計學意義（P<0.05）。結(jié)論 阿莫西林聯(lián)合奧美拉唑能夠有效改善消化道潰瘍合并上消化道出血的臨床癥狀，臨床效果較好，且不良反應的發(fā)生率較低。

Objective To investigate the clinical therapeutic effect of omeprazole combined with amoxicillin in the treatment of peptic ulcer combined with upper gastrointestinal bleeding. Methods Totally 80 cases peptic ulcer combined with upper gastrointestinal bleeding patients were collected from March 2017 to March 2018 in our hospital, according to the random number divided into treatment group (40 cases) and control group (40 cases), the control group was given omeprazole, the treatment group was given omeprazole combined with amoxicillin, compared with the clinical baseline data, effect rate of clinical treatment, incidence of adverse reaction, hospital stays, the amount of bleeding and occulting blood negative time of the two groups.Results The effect rate of clinical treatment of treatment group was 35 cases (87.50%), the effect rate of clinical treatment of control group was 26 cases (65.00%), the difference was statistically significant (P<0.05). The incidence of adverse reaction of the treatment group was four cases (10.00%), the incidence of adverse reaction of the control group was 11 cases (26.50%), the difference was statistically significant (P<0.05). Compared with the control group, the hospital stays and occulting blood negative time both significantly shorten, and the amount of bleeding significantly decreased.Conclusion Omeprazole combined with amoxicillin can significantly improve the clinical symptoms of peptic ulcer combined with upper gastrointestinal bleeding, the clinical effect is high, and the incidence of adverse reaction is low.