目的 探討甲氧氯普胺輔助治療消化性潰瘍（PU）患者對微炎癥狀態(tài)、免疫功能的影響。方法 采用平行、對照、回顧性研究方法，研究時間為2016年8月-2018年2月，選擇在周口市中心醫(yī)院診治的PU患者124例，根據(jù)治療方法的不同分為觀察組與對照組各62例，對照組給予三聯(lián)療法治療，觀察組在對照組治療的基礎(chǔ)上給予甲氧氯普胺治療，兩組療程都為14 d。結(jié)果 治療后，觀察組的總有效率為98.4%，顯著高于對照組的88.7%（P<0.05）；觀察組Hp清除率為90.3%，顯著高于對照組的69.4%（P<0.05）。治療后兩組的IL-6、TNF-α水平都顯著低于治療前，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組也低于對照組，組間差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組CD4⁺顯著增加，CD8⁺顯著降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組變化優(yōu)于對照組，組間差異有統(tǒng)計學(xué)意義（P<0.05）；CD3⁺組間與組內(nèi)對比差異不顯著。結(jié)論 甲氧氯普胺輔助治療PU患者能抑制機體的微炎癥狀態(tài)，提高免疫功能，增加Hp清除率，從而提高治療效果。

Objective To investigate the effects of metoclopramide on the micro inflammatory state and immune function in patients with peptic ulcer (PU).Methods From August 2016 to February 2018, used a parallel, controlled and retrospective study, 124 cases of PU patients were selected in our hospital and were divided into the observation group and the control group of 62 patients in each groups accorded to the different treatment methods. The control group were treated with triple therapy, and the observation group were given methoxychloropp on the basis of the control group. The two group of observation times were 14 d. Results The total effective rates of the observation group was 98.4% and significantly higher than in control group (88.7%) (P<0.05); the Hp clearance rates in the observation group was 90.3% and significantly higher than in the control group (69.4%) (P<0.05). After treatment, the serum IL-6 and TNF-α of the observation group and the control group were significantly lower than those before treatment (P<0.05), and the observation group were also lower than that of the control group (P<0.05). After treatment, the CD4⁺ of the two groups were increased significantly, and the CD8⁺ were decreased significantly, the difference compared between the observation group and the control group were also statistically significant (P<0.05). There were no significant difference compared between the two groups before and after the treatment.Conclusion The metoclopramide in the treatment of PU patients can inhibit the micro inflammatory state, improve the immune function and increase the clearance rate of Hp, thereby improve the therapeutic effect.