目的 對(duì)燈盞細(xì)辛注射液聯(lián)合常規(guī)藥物治療糖尿病周圍神經(jīng)病變臨床療效和安全性進(jìn)行系統(tǒng)評(píng)價(jià)。方法 計(jì)算機(jī)檢索中國(guó)學(xué)術(shù)期刊全文數(shù)據(jù)庫(kù)（CNKI）、中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(kù)（CBM）、維普中文科技期刊數(shù)據(jù)庫(kù)（VIP）、萬(wàn)方醫(yī)學(xué)期刊全文數(shù)據(jù)庫(kù)、PubMed、Embase、Cochrane library等數(shù)據(jù)庫(kù)，檢索日期截止到2018年8月19日。根據(jù)Cochrane系統(tǒng)評(píng)價(jià)的方法進(jìn)行納入研究的篩選，提取數(shù)據(jù)和質(zhì)量評(píng)價(jià)，然后采用Revman 5.3軟件進(jìn)行Meta-分析。結(jié)果 共有23項(xiàng)研究最終進(jìn)入本系統(tǒng)評(píng)價(jià)，Meta-分析結(jié)果顯示燈盞細(xì)辛注射液聯(lián)合常規(guī)治療組患者的臨床有效率明顯優(yōu)于單純常規(guī)治療組（RR=1.42，95% CI=1.28~1.57，P<0.000 01）；在尺神經(jīng)運(yùn)動(dòng)神經(jīng)傳導(dǎo)速度、腓神經(jīng)運(yùn)動(dòng)神經(jīng)及感覺(jué)神經(jīng)傳導(dǎo)速度、正中神經(jīng)運(yùn)動(dòng)神經(jīng)及感覺(jué)神經(jīng)傳導(dǎo)速度改善方面，燈盞細(xì)辛注射液聯(lián)合常規(guī)藥物優(yōu)于單純常規(guī)藥物治療。在尺神經(jīng)感覺(jué)神經(jīng)傳導(dǎo)速度改善方面，兩組比較無(wú)統(tǒng)計(jì)學(xué)差異。結(jié)論 燈盞細(xì)辛注射液聯(lián)合常規(guī)藥物比單純常規(guī)藥物治療在改善糖尿病周圍神經(jīng)病變臨床結(jié)局上更有優(yōu)勢(shì)。

Objective Systematic evaluation of clinical efficacy and safety of Dengzhan Xixin Injection combined with conventional drugs in the treatment of diabetic peripheral neuropathy. Methods Computer retrieval of CNKI, CBM, VIP, Wanfang Database, PubMed, Embase, Cochrane library was conducted until August 19, 2018. The methods of Cochrane systematic evaluation were used to screen the included studies, extract data and do quality evaluation, and Revman 5.3 software was then used for Metaanalysis. Results A total of 23 studies were finally included in the system evaluation, and the results of Meta-analysis showed that the clinical efficiency of patients in the Dengzhanxixin Injection combined with conventional treatment group was significantly superior to that in the simple conventional treatment group (RR=1.42, 95%CI=1.28-1.57, P<0.000 01). In the improvement of ulnar nerve motor conduction velocity, peroneal nerve motor and sensory nerve conduction velocity, median nerve motor and sensory nerve conduction velocity, Dengzhanxixin Injection combined with conventional drugs is superior to simple conventional treatment. There was no statistical difference between the two groups in the improvement of ulnar nerve conduction velocity. Conclusion Dengzhan Xixin Injection combined with conventional drug is superior to conventional drug therapy in improving the clinical outcomes of diabetic peripheral neuropathy.

北京市中醫(yī)管理局資助項(xiàng)目（JJ2016-15）；北京市醫(yī)院管理局重點(diǎn)醫(yī)學(xué)專業(yè)發(fā)展計(jì)劃建設(shè)項(xiàng)目（ZYLX201812）