帕金森?。≒arkinson's Disease，PD）是中老年人常見的神經(jīng)系統(tǒng)變性疾病，其發(fā)病可受年齡、遺傳和環(huán)境等因素影響，其主要病理機(jī)制為大腦黑質(zhì)致密部多巴胺能神經(jīng)元的病變?nèi)笔?。保護(hù)多巴胺能神經(jīng)元是行之有效的方法之一，腦內(nèi)炎癥反應(yīng)、氧化應(yīng)激等均可導(dǎo)致神經(jīng)細(xì)胞的損傷。杜仲是常用補(bǔ)益中藥，具有明確的神經(jīng)保護(hù)作用，臨床常用于PD的治療，對近年杜仲及其有效成分在PD治療中的藥理作用研究進(jìn)展做一綜述，以期為杜仲在防治PD方面的開發(fā)應(yīng)用提供一定線索。

Parkinson's disease (PD) is a common neurodegenerative disease in the elderly people. Its pathogenesis can be affected by age, heredity and environment. Its main pathological mechanism is the loss of dopaminergic neurons in the substantia nigra. Protecting dopaminergic neurons is one of the effective methods. Inflammatory reaction and oxidative stress in brain can lead to damage of nerve cells. Eucommia ulmoides Oliv. is precious tonic herbs of traditional Chinese medicine with definite neuroprotective effect. It is commonly used in the treatment of PD in clinic. In this paper, the pharmacological effects and effective components in the treatment of PD in recent years are studied. This review will provide a clue for the development and application of Eucommia ulmoides Oliv. in the prevention and treatment of PD.

國家自然科學(xué)基金（81703827）