[關(guān)鍵詞]
[摘要]
近5年來(lái)中藥界學(xué)人發(fā)現(xiàn)22種中藥成分可有效保護(hù)內(nèi)皮祖細(xì)胞(EPCs)。分別通過(guò)調(diào)節(jié)氧化應(yīng)激反應(yīng)、抑制EPCs凋亡、阻遏炎癥因子的分泌、增強(qiáng)EPC動(dòng)員、遷移、分化等生物學(xué)功能發(fā)揮對(duì)EPCs的保護(hù)作用。對(duì)此做系統(tǒng)論述及整理,并總結(jié)目前研究中存在的問(wèn)題及以后的研究方向。
[Key word]
[Abstract]
In the past five years, Chinese medicine scholars have newly discovered 22 traditional Chinese medicine ingredients to effectively protect endothelial progenitor cells.They can protect EPCs by regulating oxidative stress response,inhibiting apoptosis of EPCs, suppressing the secretion of inflammatory factors,and enhancing the biological functions of EPC mobilization, migration and differentiation. This paper makes a systematic discussion and collation, and summarizes the existing problems and future research directions.
[中圖分類(lèi)號(hào)]
[基金項(xiàng)目]
國(guó)家自然科學(xué)基金項(xiàng)目(81173164及81573852);山東省教育廳高等學(xué)??蒲许?xiàng)目(J10LF54)