小檗屬植物資源豐富，藥用歷史悠久，可用于治療多種疾病，其中刺檗、具芒小檗、毛葉黃耆和豪豬刺等植物的研究較為深入。小檗屬植物的主要成分為生物堿類和黃酮類，研究最多的是小檗堿，其具有降血糖血脂、抗炎、抑菌等藥理作用，可用于治療糖尿病及其并發(fā)癥。然而，對(duì)小檗堿的研究并不能代替對(duì)小檗屬植物的研究。對(duì)小檗屬植物提取物抗糖尿病及其并發(fā)癥的藥理作用和作用機(jī)制進(jìn)行綜述，為促進(jìn)該屬植物及其有效成分的臨床應(yīng)用提供理論基礎(chǔ)。

Berberis plants are rich in resources and have a long history of medicinal use, and they can be used to treat a variety of diseases. Among them, plants such as B. integerrima, B. aristata, B. vulgaris, B. microphylla, and B. julianae are studied deeper. The main components of the genus Berberis are alkaloids and flavonoids, and the most studied agent is berberine. It has pharmacological effects such as hypoglycemic, anti-inflammatory, antibacterial, etc., which can be used to treat diabetes and its complications. However, the study of berberine is not a substitute for the study of Berberis plants. This paper summarizes the pharmacological studies and its mechanism of action on the anti-diabetes and its complications of Berberis extract, so as to provide theoretical basis for promoting the clinical application of Berberis plants and its components.