腸道菌群作為人體內一個復雜的微生態(tài)系統(tǒng)，在維持宿主生理功能上起非常重要的作用，也與許多代謝性疾病、免疫性疾病有著密切的關系。分析睡眠剝奪與腸道菌群紊亂相關性研究的提出和再提出，綜合分析腸道菌群紊亂與睡眠障礙的關系，為以腸道菌群為靶點的改善睡眠藥物開發(fā)及防治方法與思路提供參考。

As a comlex microecosystem, gut microbiota plays an important role in maintaining the host physiological function and is also closely related to many metabolic diseases and immune diseases. In this review, we comprehensively analyze the relationship between gut microbiota disorder and sleep disturbances, based on the two times emerging researches of the correlation between sleep deprivation and gut microbiota disorder over the past few decades. The analysis may provide indication for drug development and prevention approaches targeting gut microbiota to improve sleep.

國家自然科學基金面上項目（81274114）