目的 探討米索前列醇聯(lián)合依沙吖啶在中晚期妊娠引產中的應用效果。方法 選取西安交通大學附屬3201醫(yī)院2012年1月—2017年12月收治的138例中晚期妊娠引產患者，按引產方式分為對照組、觀察組，各69例。對照組使用乳酸依沙吖啶注射液進行引產，觀察組在對照組的基礎上聯(lián)合使用米索前列醇進行引產。比較兩組引產效果、胎兒娩出時間、陰道出血量及不良反應的發(fā)生情況。結果 觀察組引產有效率是100%，顯著高于對照組的91.75%（P<0.05）。觀察組胎兒娩出時間<35 h的人數(shù)占比顯著高于對照組（P<0.05）。觀察組患者陰道出血量顯著低于對照組（P<0.05），兩組不良反應的發(fā)生率間差異不顯著。結論 米索前列醇聯(lián)合依沙吖啶在中晚期妊娠引產中的效果較好，可顯著提高引產有效率、縮短胎兒娩出時間，值得臨床應用。

Objective To explore the clinical efficacy of combined use of ethacridine and misoprostol in induction of labor in middle and late pregnancy.Methods Selected 138 patients with with induction of labor in the middle and late pregnancy from January 2012 to December 2017 in our hospital. All patients were divided into control group and observation group by induction of labor, each of group of 69 cases. Control group used induction of lactate ethacridine injection, the observation group combined with misoprostol for induction of labor based on the control group. The effects of induced labor, fetal delivery time, vaginal bleeding and adverse reactions in the two groups were compared. Results The effective rate of induction of labor in the observation group was 100%, which was significantly higher than that of the control group (91.75%) (P<0.05). The proportion of the fetus whose delivery time was < 35 h in the observation group was significantly higher than that in the control group (P<0.05). The amount of vaginal bleeding in the observation group was significantly lower than that in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups. Conclusions The combination of ethacridine and misoprostol is effective in induction of labor in middle and late pregnancy. It can significantly improve the induction efficiency and shorten the delivery time of fetus. It is worthy of clinical application.