th People's Liberation Army of China from January to December 2017 conducted prospective study, according to random number method divided into observation group (45 cases) and control group (45 cases), the control group was given omeprazole, amoxicillin combined with metronidazole, the observation group was given rabeprazole, amoxicillin combined with metronidazole, the two groups treatment for four weeks, and compared with the clinical effective rate, the abdominal distension, abdominal pain, sour regurgitation and belching time and the incidence of adverse reaction of the two groups. Results The effective rate of the observation group is 91.11%, the effective rate of the control group is 73.33%, the difference was statistically significant (P<0.05). Compared with the control group, the abdominal distension, abdominal pain, sour regurgitation and belching time significantly shortened, the difference was statistically significant (P<0.05). The incidence of adverse reaction of the observation group is 13.33%, the incidence of adverse reaction of the control group is 17.78%, the difference was not statistically significant. Conclusion Rabeprazole, amoxicillin combined with metronidazole with Helicobacter pylori has good clinical efficacy, can effectively improve the patient's clinical symptoms, with positive clinical significance."/>