目的 探討雷貝拉唑、阿莫西林聯(lián)合甲硝唑?qū)τ拈T螺旋桿菌的臨床效果。方法 選取2016年1月—2017年12月于中國(guó)人民解放軍第464醫(yī)院診治的幽門螺旋桿菌患者90例進(jìn)行前瞻性研究，采用隨機(jī)數(shù)字法分為觀察組（45例）和對(duì)照組（45例），對(duì)照組患者給予奧美拉唑、阿莫西林聯(lián)合甲硝唑，觀察組患者給予雷貝拉唑、阿莫西林聯(lián)合甲硝唑，兩組患者均接受治療4周。比較兩組患者臨床治療有效率，腹脹、腹痛、反酸及噯氣的緩解時(shí)間及不良反應(yīng)發(fā)生率。結(jié)果 觀察組患者的有效率為91.11%，對(duì)照組患者的治療有效率為73.33%，差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。與對(duì)照組相比，觀察組患者的腹脹、腹痛、反酸及噯氣緩解時(shí)間均顯著縮短，差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。觀察組患者的不良反應(yīng)發(fā)生率為13.33%，對(duì)照組患者的不良反應(yīng)發(fā)生率為17.78%，差異無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論 雷貝拉唑、阿莫西林聯(lián)合甲硝唑?qū)τ拈T螺旋桿菌的臨床治療效果較好，能夠有效改善患者的臨床癥狀，具有積極的臨床意義。

Objective To investigate the clinical efficacy of rabeprazole, amoxicillin combined with metronidazolein the treatment of Helicobacter pylori. Methods 90 patients with helicobacter pylori were collected in 464^th People's Liberation Army of China from January to December 2017 conducted prospective study, according to random number method divided into observation group (45 cases) and control group (45 cases), the control group was given omeprazole, amoxicillin combined with metronidazole, the observation group was given rabeprazole, amoxicillin combined with metronidazole, the two groups treatment for four weeks, and compared with the clinical effective rate, the abdominal distension, abdominal pain, sour regurgitation and belching time and the incidence of adverse reaction of the two groups. Results The effective rate of the observation group is 91.11%, the effective rate of the control group is 73.33%, the difference was statistically significant (P<0.05). Compared with the control group, the abdominal distension, abdominal pain, sour regurgitation and belching time significantly shortened, the difference was statistically significant (P<0.05). The incidence of adverse reaction of the observation group is 13.33%, the incidence of adverse reaction of the control group is 17.78%, the difference was not statistically significant. Conclusion Rabeprazole, amoxicillin combined with metronidazole with Helicobacter pylori has good clinical efficacy, can effectively improve the patient's clinical symptoms, with positive clinical significance.