目的 系統(tǒng)評價泮托拉唑對比奧美拉唑治療胃潰瘍的療效和安全性。方法 計算機檢索PubMed、EmBase、Cochrane Library、中國學術期刊全文數(shù)據庫（CNKI）、中國生物醫(yī)學文獻數(shù)據庫（CBM）、維普中文期刊全文數(shù)據庫（VIP）和萬方數(shù)據庫，從建庫至2018年7月公開發(fā)表的泮托拉唑和奧美拉唑治療胃潰瘍的隨機臨床對照試驗（RCT），由兩位研究者獨立篩選評價文獻并提取資料，采用RevMan 5.3軟件行系統(tǒng)評價。結果 共納入15項RCTs，合計1 482例患者。Meta-分析結果顯示：泮托拉唑組相對于奧美拉唑組在潰瘍治愈率［RR=1.12，95% CI（1.02，1.24），P=0.02］和幽門螺桿菌根除率［RR=1.40，95% CI（1.22，1.61），P<0.000 01］方面的差異均有統(tǒng)計學意義；兩組總有效率［RR=1.03，95% CI（1.00，1.07），P=0.09］以及不良反應發(fā)生率［RR=1.34，95% CI（0.89，2.04），P=0.16］比較無顯著性差異。結論 泮托拉唑的胃潰瘍治愈率和幽門螺桿菌根除率優(yōu)于奧美拉唑，兩者總有效率和不良反應發(fā)生率相當，安全性、耐受性均較好。

Objective To systematically review the efficacy and safety of pantoprazole versus omeprazole in treatment of gastric ulcer (GU). Method Retrieving published randomized controlled clinical trials about pantoprazole versus omeprazole in treatment of gastric ulcer in PubMed, EmBase, Cochrane Library, CNKI, CBM, VIP and Wanfang from the foundation of database to July 2018, then making the Meta-analysis by RevMan 5.3. Results A total of 15 RCTs involving 1 482 patients were included. The Metaanalysis results showed that compared with omeprazole, there was a significant difference (P<0.05) in treatment group with regard to GU cure rate[RR=1.12, 95%CI(1.02, 1.24), P=0.02] and Helicobacter pylori eradication rate[RR=1.40, 95%CI(1.22, 1.61), P< 0.000 01]. There were no significant differences (P>0.05) among the total effective rate[RR=1.03, 95%CI(1.00, 1.07), P=0.09] and adverse reaction (ADR) incidence[RR=1.34, 95%CI(0.89, 2.04), P=0.16] in 2 groups. Conclusion The cure rate and H.pylori eradication rate of pantoprazole are better than omeprazole. Pantoprazole and omeprazole have similar total effective rate and ADR incidence in the treatment of GU. The safety and tolerance are all acceptable.