亞胺培南是一種碳青霉烯類抗生素，在臨床上和西司他丁組成復(fù)方制劑，用于多重耐藥和重癥感染的治療。腎毒性是亞胺培南的常見不良反應(yīng)，在兒童和老年等腎功不全群體中，應(yīng)用亞胺培南導(dǎo)致腎臟毒性的風(fēng)險(xiǎn)更大。西司他丁具有腎保護(hù)活性，可降低順鉑、萬古霉素、環(huán)孢素A等藥物的腎毒性。本文對近年來亞胺培南腎毒性和西司他丁腎保護(hù)作用的研究進(jìn)展進(jìn)行綜述，從基礎(chǔ)研究和臨床應(yīng)用的角度，揭示亞胺培南和西司他丁在腎臟產(chǎn)生不同效應(yīng)的可能機(jī)制，為亞胺培南和西司他丁的臨床安全合理應(yīng)用提供理論基礎(chǔ)和科學(xué)建議。

Imipenem is a carbapenem antibiotic with a broad antimicrobial activity. Imipenem is prescribed with Cilastatin together to treat mixed and serious infections. Nephrotoxicity is a common adverse effect in Imipenem treated patients, especially in pediatric and aging patients with impaired renal function. Cilastatin is a potential therapeutic agent to protect against nephrotoxicity induced by vancomycin, cisplatin, and cyclosporin A. In present study, preclinical studies and clinical observations of Imipenem nephrotoxicity and renal protection of Cilastatin were reviewed to explore the effects and mechanisms of Imipenem and Cilastatin on kidney and provide scientific advices for the safe and rational clinical application of Imipenem and Cilastatin.

國家自然科學(xué)基金項(xiàng)目（81874324）