氧化苦參堿具有抗高脂飲食性、CCl₄性、CCl₄/酒精性、二甲基亞硝胺性、半乳糖胺性、免疫性慢性肝損傷作用。氧化苦參堿是通過抗氧化、抗炎作用，減輕肝臟的氧化應(yīng)激和炎癥反應(yīng)以及抑制成纖維細胞和肝星狀細胞的活化以及細胞外基質(zhì)生成，產(chǎn)生抗肝纖維化作用。氧化苦參堿還可通過促進胰島素信號轉(zhuǎn)導(dǎo)，改善胰島素抵抗，抑制肝細胞吸收長鏈脂肪酸和脂肪酸合成并加速游離脂肪酸的β-氧化，產(chǎn)生抗脂肪肝作用。

Oxymatrine has the effects to antagonize chronic liver injuries induced by high-fat diet, CCl₄, CCl₄/alcohol, dimethylnitrosamine, galactosamine, and immunity. Oxymatrine alleviates oxidative stress and inflammation of liver by antioxydation and anti-inflammation, decreases hepatic fibrosis by inhibiting activation of HSC and fibroblast, and inhibites synthesis of extracellular matrix. Oxymatrine has the effect against fatty liver by promoting insulin signal transduction to alleviate insulin resistance, inhibiting hepatocyte to absorb the long chain fatty acid, decreasing synthesis of fatty acid, and accelerating β-oxidation of free fatty acid.