介紹用番瀉葉復(fù)制小鼠腹瀉模型的規(guī)范操作。以稀便率與稀便級的乘積表示的腹瀉指數(shù)作為主要觀察指標(biāo)，它可以全面反映個體動物的腹瀉程度并具有可比性。結(jié)果表明：小鼠的腹瀉指數(shù)呈正態(tài)分布；各造型組組間的腹瀉指數(shù)無差異；同組小鼠連續(xù)6d造型其腹瀉指數(shù)也無差異，表現(xiàn)出良好的重現(xiàn)性。該模型可推薦作為篩選抗腹瀉藥物使用。

In Order to screen antidiarrhea drugs, the standard operation of mice diarrhea model replicated with leave of Cassia angustifolia vahl was introduced. In experiments, diarrhea index expressed with loose stool ineidence rate multiplied by loose stool grade was used as main index. It thoroughly mirrors indi. vidual diarrhea degree and possesses comparability. The result indicates that diarrhea index in mice presented normal distribution. The index between animal model groups kad no difference as well as no differcnce was found in model mice of same group for six consecutive days, with good reproduclbility. It is recommended that the model can be used for the screening of antidiarrhea drugs