將伸筋草提取液分別用超濾法和水醇法制成注射液,分組對(duì)染塵大鼠腹腔注射給藥5周,解剖后測(cè)定各組大鼠肺的鮮重、干重、膠原含量和病理分級(jí)等指標(biāo),結(jié)果表明．用超濾法制備的注射液預(yù)防性治療給藥對(duì)大鼠實(shí)驗(yàn)性矽肺有較好療效,而用水醇法制備的注射液療效不佳。還對(duì)伸筋草的抗矽有效成分進(jìn)行了探討。

Shenjincao injection was prepared from the extract of Lycopodium cernuum L. by ultrafiltration or wateralcohol methods,respectively,and then injected intra-peritoneally in groups of rats contaminated with quartz powder to assess their prophylactic effects. After 5 weeks of treatment,the rats were dissected and the fresh and dried weights,collagen content and the pathologic grading of the lungs were examined. Results showed that Shenjincao injection prepared with ultrafiltration was effective for the prophylactic treatment of experimental silicnsis of rats,while that prepared with water-alcohol method was devoid of such effect. The antisilicosis active principle of Shenjincao was explored and discussed.

鐵道部“八五”重點(diǎn)衛(wèi)生科研課題