將伸筋草提取液分別用超濾法和水醇法制成注射液,分組對染塵大鼠腹腔注射給藥5周,解剖后測定各組大鼠肺的鮮重、干重、膠原含量和病理分級等指標(biāo),結(jié)果表明．用超濾法制備的注射液預(yù)防性治療給藥對大鼠實驗性矽肺有較好療效,而用水醇法制備的注射液療效不佳。還對伸筋草的抗矽有效成分進行了探討。

Shenjincao injection was prepared from the extract of Lycopodium cernuum L. by ultrafiltration or wateralcohol methods,respectively,and then injected intra-peritoneally in groups of rats contaminated with quartz powder to assess their prophylactic effects. After 5 weeks of treatment,the rats were dissected and the fresh and dried weights,collagen content and the pathologic grading of the lungs were examined. Results showed that Shenjincao injection prepared with ultrafiltration was effective for the prophylactic treatment of experimental silicnsis of rats,while that prepared with water-alcohol method was devoid of such effect. The antisilicosis active principle of Shenjincao was explored and discussed.

鐵道部“八五”重點衛(wèi)生科研課題