采用膽固醇飼喂日本大耳白家兔3個(gè)月,以造成主動脈粥樣硬化病變模型,在建立動物模型的同時(shí),給予疏肝活血復(fù)方中藥,待實(shí)驗(yàn)結(jié)束時(shí),取血測試,觀察該中藥對血鈣濃度,血漿環(huán)核苷酸濃度的影響,結(jié)果顯示,該中藥可明顯降低Ca2＋濃度,升高環(huán)磷酸腺苷(cAMP)／環(huán)磷酸鳥苷(cGMP)比值.提示疏肝活血方對動脈粥樣硬化(As)的防治起到積極作用.

Atherosclerotic model of rabbit was established by feeding cholesterol for three months.At the sametime,part of the animals were treated with prescription to soothe,the liver and promote blood circulation.Blood samples were taken at the end of the experiment to examine the effect on blood calcium concentrationand cyclic nucleoside-phosphate content.Results showed that the prescription could significantly reduce bloodcalcium,and raise cAMP/cGMP ratio which suggested that the prescription could restrain the formation ofatherosclerosis effectively,and also delay its development.

天津市自然科學(xué)基金