鬼針草中的新天然成分──鬼針聚炔甙(bipinnatpolyacetylenicloside)能明顯抑制巴豆油誘發(fā)的小鼠耳殼腫脹及蛋清性足腫脹,降低大鼠棉球肉芽腫重量,還能顯著抑制小鼠毛細(xì)血管通透性和醋酸至炎的大鼠的白細(xì)胞游走,其抗炎效果大多與地塞米松組無顯著差異甚至有的作用略強(qiáng),鬼針草中的黃酮混晶也有較好的抗炎作用。

Bipinnatpolyacetylenic loside-anew natural constituent isolated from Bidens bipinnata,produced sig-nificant inhibitory effects on swelling of mice ear induced by croton oil and hind paw edema induced by egg white,decreased the weight of cotton pellet granuloma implanted in rats,and also greatly inhibited blood cap-illary permeability of mice and leukocyte movement induced by acetic acid in rats. Compared with that of dex-amethasone,no significant difference and even slightly more potent effects were observed. The flavones in B.bipinnata also exhibited better anti-inflammatory effects.

山東省自然科學(xué)基金