應(yīng)用高效液相色譜法（HPLC）觀察了狗皮巴布膏體外經(jīng)皮滲透性，采用兩室擴(kuò)散模型對(duì)脫毛小鼠皮進(jìn)行了實(shí)驗(yàn)觀察。結(jié)果表明狗皮膏巴布劑透皮吸收的可行性，其透皮量隨著藥物濃度的增加和時(shí)間的延長(zhǎng)而增多，低濃度12.5mg生藥／mL在180min時(shí)的累積透皮量已不再增加。此結(jié)果為狗皮膏巴布劑的臨床應(yīng)用提供了實(shí)驗(yàn)基礎(chǔ)。

Percutaneous absorption of Goupibabu Plaster was studied using HPLC, adopting simple diffusion cell model to observe its permeation through hairless mouse skin. The result showed that Goupibabu plaster can evidently permeate through the skin,and the amount absorbed increased exponentially with content and time.