用3月齡去卵巢SD大鼠為模型，4.5mg／L已烯雌酚（diethylstilbestoli，DES）和1kg／L黃芪水提液5mL／kg·dig，每周6次，持續(xù)12周，脛骨近端不脫鈣骨片測(cè)量。結(jié)果：去卵巢組大鼠的骨形成和骨吸收均增加，但骨吸收大于骨形成，骨質(zhì)丟失（％Tb.Ar—68％）；黃芪水提液和DES能有效防止去卵巢大鼠的骨丟失，效應(yīng)相近（與去卵巢組比較％Tb.Ar分別＋122％和＋85％，兩個(gè)治療組間P＞0.05），但作用機(jī)理不同。黃芪水提液僅抑制去卵巢后的骨吸收，而DES則同時(shí)抑制骨吸收和骨形成，但以抑制骨吸收為主。

SD rats n-32,3-month-old,were randomly divided in groups of basal control,aging control,ovariectomiaed(OVX),OVX+DES(Diethylstilbestrol)5 mL/kg?d(4. 5mg/L)and OVX+Astragalus mem- branaceus 5mL/kg. d(1 kg/L) ig,6 times a week. After 12 weeks ,their proximal tibiae were processed to un- decalcified sections at 20 hem thickness for histomorphometric analysis. Results ; trabecullar bone mass in the OVX group reduced markedly(%Tb. Ar一68 0 o) due to bone turnover increase with bone resorption exceeded bone formation. Treatment with Huangqi and DES increased significantly the bone mass(0 o Tb. Ar+12200 and +850o respectively) as compared with OVX control. The protective effects of the two drugs appeared to be quite similar but the mechanism involved may be different. Huangqi suppresses principally bone resorption while DES inhibits bone resorption as well as bone formation. Conclusion;Results of the study showed that Huangqi and DES could prevent trabecular loss in OVX rats.

國(guó)家自然科學(xué)研究基金!39470367