采用硅膠柱預(yù)處理-HPLC對自制組曲H-18及市售組曲中的洛伐他汀進行了定量分析, 線性范圍 0.65~5.72μg/ｍL,ｒ=0.9999,加樣回收率為96.4%,RSD=3.68%。結(jié)果表明,各地產(chǎn) 紅由商品藥材中有 7種洛伐他汀未測出或只有痕量,５種含量甚微(0.088~0.551μg/g生藥),而 自制組曲H-18的洛伐他汀含量最高,達５μg/g生藥。

Hongqu,a well known TCM prepared by fermenting rice with Monascus purpureus Went (Mona scaceae),used for the promotion of blood circulation and to resolve blood stasis,was speculated to contain some "statins". Pretreatment-HPLC is applied to determine lovastatin in Hongqu H-18 made in our own laboratory and some other commercially available Hongqu samples. The standard curve is linear in the concentration range of 0. 65-57. 2μg/mL,the correlation coefficient is 0. 9999. The average recovery rate is 96.4%and relative standard deviation 3. 68%(n=5). The results showed that Hongqu from different commercial sources contain no or only a small amount of lovastatin (0. 088~0. 551μg/g), but amounted to almost 5μg/gin Hongqu H-18.