蒙藥紫花高烏頭根中二萜生物堿的分離與鑒定

張樹祥; 賈世山; Zhang Shuxiang; Jia Shishan

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主辦：天津藥物研究院中國(guó)藥學(xué)會(huì)

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首頁 > 過刊瀏覽>1999年第卷第9期 >1999(9):641-643

蒙藥紫花高烏頭根中二萜生物堿的分離與鑒定

Isolation and Identification of Diterpenoid Alkaloids from Mongolian Folk Medicine Purpleflower High Monkshood Root (Aconitum excelsum)

發(fā)布日期：2015-01-08

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[關(guān)鍵詞]

[摘要]

從紫花高烏頭根的苯提取物中分離到3個(gè)二萜生物堿,經(jīng)理化性質(zhì)和光譜分析分別鑒定為lappaconitine(I)、ranaconitine(Ⅱ)和 septentriodine(Ⅲ)?；衔?Ⅱ和Ⅲ為首次從該植物中分離到,其中Ⅱ含量最高,根據(jù)文獻(xiàn)報(bào)道Ⅰ和Ⅱ是抗心率失常和鎮(zhèn)痛作用的有效成分。

[Key word]

[Abstract]

Three diterpenoid alkaloids were obtained from the C_6H_6 extract of the root of Aconitum excelsum. Their structures were identified on the basis of spectral data (MS, IR, ~1HNMR, ~(13)CNMR, DEPT) and physico-chemical properties as lappaconitine (I), ranaconitine (Ⅱ) and septentriodine（Ⅲ). Compounds Ⅱand Ⅲ were obtained for the first time from this plant. Compounds Ⅰ and Ⅱ exhibited analgesic and antiarrhythmic activities, as documented in literature reports.

[中圖分類號(hào)]

[基金項(xiàng)目]

國(guó)家自然科學(xué)基金39560087