[關(guān)鍵詞]
[摘要]
采用改良Franz擴(kuò)散池法和人體剩余量法,研究如意金黃巴布劑中小檗堿的經(jīng)皮滲透特性,HPLC法檢測(cè)透過的小檗堿。結(jié)果表明:小檗堿可以透過皮膚而被吸收,其經(jīng)皮滲透過程符合Higuchi方程,而且兩種透皮試驗(yàn)方法具有良好的相關(guān)性。提示如意金黃巴布劑經(jīng)皮滲透效果良好,適于經(jīng)皮給藥。體外透皮試驗(yàn)在一定程度上可以反映藥物透皮吸收的真實(shí)情況。
[Key word]
[Abstract]
Percutaneous absorption of berberine from Ruyijinhuang adhesive tape was studied by improved Franz diffusing cells and residual dosage methods. The permeated berberine was determined by HPLC. The results showed that berberine in Ruyijinhuang adhesive tape could penetrate through skin and be absorbed. The process of Penetration could be described by Higuchi equation. The two percutaneous test methods showed a significant correlationship suggesting that Ruyijinhuang adhesive tape is suitable for administration through skin.
[中圖分類號(hào)]
[基金項(xiàng)目]