鐵屎米酮 5,10,2 0 m g/ kg ig可明顯提高烏頭堿致大鼠、哇巴因致豚鼠發(fā)生室性早博、室性心動過速、室顫的用量 ;降低大鼠缺血再灌性室性心律失常發(fā)生率,縮短心律失常持續(xù)時間,防止室顫的發(fā)生。表明鐵屎米酮具有抗心律失常作用

Effect of canthin-6-one (Can)(an alkaloid extracted from Zanthoxylum dimorphophylhum Hemsl. var. spinifolium Rehd. et Wils.) on experimental arrhythmia induced by aconitine, ouabain and ischemia/reperfusion was studied. Can (5, 10, 20 mg/kg, ig) was shown to increase the threshold dose of causing ventricular ectopic, ventricular tachycardia, ventricular fibrillation; decrease the incidence of arrhythmia induced by ischemia/reperfusion, shorten duration of ventricular arrhythmia and eliminate the incidence of ventricular fibrillation. These results suggested that canthin-6-one has a protective effect on experimental arrhythmia.